热疗对V79细胞中紫外线和N-甲基-N'-硝基-N-亚硝基胍诱导的杀伤和突变的调节作用。
Hyperthermia-induced modulation of killing and mutation by UV and N-methyl-N'-nitro-N-nitrosoguanidine in V79 cells.
作者信息
Banerjee S, Bhaumik G, Bhattacharjee S B
机构信息
Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Calcutta, India.
出版信息
Mutat Res. 1989 May;226(1):69-73. doi: 10.1016/0165-7992(89)90096-1.
PMID:2716772
Abstract
Hyperthermic exposures of V79 cells did not affect the killing by UV light, whereas it enhanced MNNG-induced killing. Such hyperthermic exposure increased the mutation induction (resistance to 6-thioguanine) by both UV and MNNG. The timing of heat exposure, before or after the treatments, had no effect on the result in cases of cytotoxicity and mutagenesis.
摘要
对V79细胞进行热暴露并不影响紫外线的杀伤作用，然而却增强了N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱导的杀伤作用。这种热暴露增加了紫外线和MNNG两者诱导的突变（对6-硫鸟嘌呤的抗性）。在处理之前或之后进行热暴露的时间，对细胞毒性和诱变作用的结果均无影响。
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