Meekings Adam, Utz Sarah, Ulrich Martina, Bienenfeld Amanda, Nandanan Naveen, Fisher Juliya, McKenzie Gordon, Siegel Daniel M, Feldman Eleanor, Markowitz Orit
J Drugs Dermatol. 2016 May 1;15(5):545-50.
Optical coherence tomography (OCT) is a technique that enables real-time in-vivo examination of tissue. This technology provides the clinician with the potential to use a non-invasive tool in the identification and diagnosis of many skin lesions. However, the diagnostic features of basal cell carcinoma have not yet been described with comparison to their histopathology.
To identify and describe key features of basal cell carcinoma (BCC) and its subtypes as they present in multi-beam Swept Source - OCT (MSS-OCT), and to correlate those against conventional histopathology.
A total of 40 lesions were assessed by MSS-OCT prior to biopsy. 60-slice OCT images of the lesions were obtained and correlated with histology sections taken in the same plane. OCT scans were assessed retrospectively by a panel to determine the OCT criteria for BCC and its subtypes.
The following diagnostic criteria were identified: hyporeflective ovoid structures (40/40), dark halo boundaries (38/40), epidermal thinning (28/40), and collagen compression (14/40). Lesional tissue also showed a destruction of layers when compared to the surrounding normal tissue. In addition to the shared criteria, other subtypes showed distinct diagnostic criteria.
With its higher sensitivity, using MSS-OCT allowed for non-invasive, accurate identification of the key diagnostic features of BCC and its subtypes with high correlation to the histopathologic features found with biopsy.
J Drugs Dermatol. 2016;15(5):545-550.
光学相干断层扫描（OCT）是一种能够对组织进行实时体内检查的技术。这项技术为临床医生提供了使用非侵入性工具来识别和诊断多种皮肤病变的可能性。然而，与组织病理学相比，基底细胞癌的诊断特征尚未得到描述。
识别并描述多光束扫频源光学相干断层扫描（MSS-OCT）中基底细胞癌（BCC）及其亚型的关键特征，并将这些特征与传统组织病理学进行关联。
在活检前，通过MSS-OCT对总共40个病变进行评估。获取病变的60层OCT图像，并与同一平面上获取的组织学切片进行关联。由一个小组对OCT扫描进行回顾性评估，以确定BCC及其亚型的OCT标准。
确定了以下诊断标准：低反射卵形结构（40/40）、暗晕边界（38/40）、表皮变薄（28/40）和胶原压缩（14/40）。与周围正常组织相比，病变组织还显示出层次破坏。除了共享标准外，其他亚型还显示出不同的诊断标准。
由于其更高的灵敏度，使用MSS-OCT能够非侵入性、准确地识别BCC及其亚型的关键诊断特征，且与活检发现的组织病理学特征高度相关。
《药物皮肤病学杂志》2016年；15（5）：545 - 550。
