Gangidine Matthew M, Blakeman Thomas C, Branson Richard D, Johannigman Jay A
Division of Trauma and Critical Care, Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45255.
Mil Med. 2016 May;181(5 Suppl):177-83. doi: 10.7205/MILMED-D-15-00150.
Addition of an oxygen concentrator into a control loop furthers previous work in autonomous control of oxygenation. Software integrates concentrator and ventilator function from a single control point, ensuring maximum efficiency by placing a pulse of oxygen at the beginning of the breath. We sought to verify this system.
In a test lung, fraction of inspired oxygen (FIO2) levels and additional data were monitored. Tests were run across a range of clinically relevant ventilator settings in volume control mode, for both continuous flow and pulse dose flow oxygenation.
Results showed the oxygen concentrator could maintain maximum pulse output (192 mL) up to 16 breaths per minute. Functionality was verified across ranges of tidal volumes and respiratory rates, with and without positive end-expiratory pressure, in continuous flow and pulse dose modes. For a representative test at respiratory rate 16 breaths per minute, tidal volume 550 mL, without positive end-expiratory pressure, pulse dose oxygenation delivered peak FIO2 of 76.83 ± 1.41%, and continuous flow 47.81 ± 0.08%; pulse dose flow provided a higher FIO2 at all tested setting combinations compared to continuous flow (p < 0.001).
These tests verify a system that provides closed loop control of oxygenation while integrating time-coordinated pulse-doses from an oxygen concentrator. This allows the most efficient use of resources in austere environments.
在控制回路中添加氧气浓缩器是对先前自主控制氧合工作的进一步拓展。软件从单一控制点整合浓缩器和呼吸机功能，通过在呼吸开始时输送一股氧气脉冲来确保最大效率。我们试图验证该系统。
在一个测试肺中，监测吸入氧分数（FIO₂）水平及其他数据。在容量控制模式下，针对连续流和脉冲剂量流氧合，在一系列临床相关的呼吸机设置下进行测试。
结果显示，氧气浓缩器在每分钟高达16次呼吸时可维持最大脉冲输出（192毫升）。在连续流和脉冲剂量模式下，无论有无呼气末正压，在潮气量和呼吸频率的范围内功能均得到验证。在呼吸频率为每分钟16次、潮气量为550毫升且无呼气末正压的代表性测试中，脉冲剂量氧合的峰值FIO₂为76.83±1.41%，连续流为47.81±0.08%；与连续流相比，在所有测试的设置组合中，脉冲剂量流提供了更高的FIO₂（p<0.001）。
这些测试验证了一个在整合来自氧气浓缩器的时间协调脉冲剂量的同时提供氧合闭环控制的系统。这使得在严峻环境中能够最有效地利用资源。
