Newberry N R, Connolly G P
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, U.K.
Neuropharmacology. 1989 Feb;28(2):149-52. doi: 10.1016/0028-3908(89)90051-8.
The pharmacology of two muscarinic responses, recorded from the ventral roots of the spinal cord in the neonatal rat, have been compared: the depolarising response and the inhibition of the monosynaptic compound action potential (CAP). Pirenzepine was more potent than AF-DX 116 in antagonising the depolarising response. However, the potencies of these compounds indicated that this response may be mediated by neither M1 nor M2 (cardiac-like) receptors. The drug AF-DX 116 (1 microM), but not pirenzepine, selectively reduced the inhibitory effect. It is concluded that the receptors mediating these two responses are different.
去极化反应和单突触复合动作电位（CAP）的抑制。哌仑西平在拮抗去极化反应方面比AF-DX 116更有效。然而，这些化合物的效能表明该反应可能既不是由M1受体也不是由M2（类心脏）受体介导的。药物AF-DX 116（1 microM）而非哌仑西平选择性地降低了抑制作用。得出的结论是，介导这两种反应的受体是不同的。
