Pieralli Annalisa, Fallani Maria Grazia, Becorpi Angelamaria, Bianchi Claudia, Corioni Serena, Longinotti Manuela, Tredici Zelinda, Guaschino Secondo
Section of Gynecology and Obstetrics, Department of Woman and Child Health, Careggi University Hospital, Largo Brambilla 3, 50144, Florence, Italy.
, Largo Brambilla 3, 50134, Florence, Italy.
Arch Gynecol Obstet. 2016 Oct;294(4):841-6. doi: 10.1007/s00404-016-4118-6. Epub 2016 May 12.
The aim of this study was to evaluate the efficacy of fractional CO2 laser therapy in breast cancer survivors as a therapeutic method for vulvovaginal atrophy (VVA) dyspareunia.
50 patients (mean age 53.3 years) underwent fractional microablative CO2 laser treatment for dyspareunia in oncological menopause (mean time of menopause 6.6 years). The Gloria Bachmann's Vaginal Health Index (VHI) score was chosen as system to evaluate the presence of VVA and its improvement after the treatment. Intensity of dyspareunia was evaluated using a visual analog scale (VAS).
Data indicated a significant improvement in VVA dyspareunia (p < 1.86e-22) in breast cancer survivors who had undergone 3 sessions of vaginal fractional CO2 laser treatment. Moreover, VHI scores were significantly higher 30 days post-treatment (T4) (p < 0.0001). 76 % of patients were satisfied or very satisfied with the treatment results. The majority (52 %) of patients were satisfied after a long-term follow-up (mean time 11 months). No adverse events due to fractional CO2 laser treatment occurred.
The treatment with fractionated CO2 laser appeared to be a feasible and effective treatment for VVA dyspareunia in breast cancer survivors with contraindications to hormonal treatments.
本研究旨在评估分次二氧化碳激光治疗对乳腺癌幸存者外阴阴道萎缩（VVA）性性交困难的疗效。
50例患者（平均年龄53.3岁）因肿瘤性绝经（平均绝经时间6.6年）导致的性交困难接受了分次微剥脱二氧化碳激光治疗。选择格洛丽亚·巴赫曼阴道健康指数（VHI）评分作为评估VVA的存在及其治疗后改善情况的系统。使用视觉模拟量表（VAS）评估性交困难的程度。
数据表明，接受3次阴道分次二氧化碳激光治疗的乳腺癌幸存者的VVA性性交困难有显著改善（p < 1.86e - 22）。此外，治疗后30天（T4）的VHI评分显著更高（p < 0.0001）。76%的患者对治疗结果满意或非常满意。大多数（52%）患者在长期随访（平均时间11个月）后感到满意。未发生因分次二氧化碳激光治疗导致的不良事件。
对于有激素治疗禁忌证的乳腺癌幸存者，分次二氧化碳激光治疗似乎是一种可行且有效的VVA性性交困难治疗方法。
