Karjalainen T K, Tomich C E
Department of Pathology, Indiana University School of Medicine, Indianapolis.
Oral Surg Oral Med Oral Pathol. 1989 May;67(5):547-54. doi: 10.1016/0030-4220(89)90271-5.
Specimens representing 17 cases of each of oral mucosal lupus erythematosus (LE) and lichen planus were examined under the light microscope to establish a set of histopathologic criteria that would distinguish between the two. Statistical analysis showed that significant differences in histopathology exist between the two diseases. A classic case of LE was found to exhibit the following characteristics: vacuolization of keratinocytes, patchy PAS-positive deposits subepithelially, edema in the lamina propria, PAS-positive thickening of blood vessel walls, and the presence of a severe or perivascular inflammatory cell infiltrate. A number of other less significant alterations were also identified. It is concluded from this study that oral LE in most cases is characteristic enough to provide a definitive diagnosis at the light microscopic level.
对17例口腔黏膜红斑狼疮（LE）和扁平苔藓的标本进行了光镜检查，以建立一套能够区分这两种疾病的组织病理学标准。统计分析表明，这两种疾病在组织病理学上存在显著差异。发现一例典型的LE表现出以下特征：角质形成细胞空泡化、上皮下散在的PAS阳性沉积物、固有层水肿、血管壁PAS阳性增厚以及严重或血管周围炎性细胞浸润。还发现了一些其他不太显著的改变。该研究得出结论，大多数情况下，口腔LE具有足够的特征性，能够在光镜水平上做出明确诊断。
