Turner Taylor B, Buchsbaum Donald J, Straughn J Michael, Randall Troy D, Arend Rebecca C
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
Gynecol Oncol. 2016 Aug;142(2):349-56. doi: 10.1016/j.ygyno.2016.05.007. Epub 2016 May 23.
The majority of patients with epithelial ovarian cancer are diagnosed with advanced disease. While many of these patients will respond initially to chemotherapy, the majority will relapse and die of their disease. Targeted therapies that block or activate specific intracellular signaling pathways have been disappointing. In the past 15years, the role of the immune system in ovarian cancer has been investigated. Patients with a more robust immune response, as documented by the presence of lymphocytes infiltrating within their tumor, have increased survival and better response to chemotherapy. In addition, a strong immunosuppressive environment often accompanies ovarian cancer. Recent research has identified potential therapies that leverage the immune system to identify and destroy tumor cells that previously evaded immunosurveillance mechanisms. In this review, we discuss the role of the immune system in ovarian cancer and focus on specific pathways and molecules that show a potential for targeted therapy. We also review the ongoing clinical trials using targeted immunotherapy in ovarian cancer. The role of targeted immunotherapy in patients with ovarian cancer represents a field of growing research and clinical importance.
大多数上皮性卵巢癌患者在确诊时已处于晚期。虽然这些患者中的许多人最初会对化疗产生反应，但大多数人会复发并死于该疾病。阻断或激活特定细胞内信号通路的靶向治疗效果并不理想。在过去15年里，免疫系统在卵巢癌中的作用已得到研究。肿瘤内有淋巴细胞浸润证明免疫反应更强的患者，生存期延长且对化疗反应更好。此外，卵巢癌常伴有强大的免疫抑制环境。最近的研究已确定了一些潜在疗法，这些疗法利用免疫系统来识别和摧毁先前逃避免疫监视机制的肿瘤细胞。在本综述中，我们讨论了免疫系统在卵巢癌中的作用，并重点关注显示出靶向治疗潜力的特定信号通路和分子。我们还回顾了正在进行的卵巢癌靶向免疫治疗临床试验。靶向免疫治疗在卵巢癌患者中的作用是一个研究和临床重要性不断增加的领域。
