TIM-3 在卵巢癌中的作用。
Role of TIM-3 in ovarian cancer.
机构信息
Department of Gynecology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, Jiangsu Province, China.
Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.
出版信息
Clin Transl Oncol. 2017 Sep;19(9):1079-1083. doi: 10.1007/s12094-017-1656-8. Epub 2017 Mar 29.
Evidences have suggested that immunotherapy for ovarian cancer is effective. Immune checkpoints have emerged in the field of cancer immunotherapy. Multiple studies have shown negative regulation of TIM-3 expression on CD4 and CD8 T cells and other immunocytes. Overexpression of TIM-3 in innate immune cells has been found in certain types of tumor. The blockade of TIM-3 leads to sustained anti-tumor reactions. TIM-3 plays an inhibitive role for immunity in ovarian cancer. TIM-3 is involved in the development of various subtypes of ovarian cancer and thus has the potential to be a therapeutic target for treatment of ovarian cancer.
有证据表明，卵巢癌的免疫疗法是有效的。免疫检查点已经出现在癌症免疫疗法领域。多项研究表明，TIM-3 在 CD4 和 CD8 T 细胞和其他免疫细胞上的表达受到负调控。在某些类型的肿瘤中发现了先天免疫细胞中 TIM-3 的过度表达。TIM-3 的阻断导致持续的抗肿瘤反应。TIM-3 在卵巢癌的免疫中起抑制作用。TIM-3 参与了各种亚型的卵巢癌的发展，因此有可能成为治疗卵巢癌的治疗靶点。
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