Hussain M A, DiLuccio R C, Shefter E
E. I. du Pont de Nemours & Company, Medical Products Department, Wilmington, Delaware 19898.
Pharm Res. 1989 Jan;6(1):49-52. doi: 10.1023/a:1015847618671.
Phenylpropanolamine (PPA) bound to ion-exchange resin was encapsulated in hollow fibers made of segmented polyurethane. This system was examined as an oral sustained-release delivery system. The fibers were spun by the phase inversion process and cut into different aspect ratios (length/diameter). The U.S.P. basket dissolution method was used to evaluate the in vitro drug release kinetics and the effect of the aspect ratio on the release. For in vivo evaluation, selected fibers were orally administered to dogs in gelatin capsules. The fiber delivery system provided a sustained-release profile of plasma PPA and a longer terminal half-life when compared to an oral immediate-release formulation.
与离子交换树脂结合的苯丙醇胺（PPA）被包裹在由嵌段聚氨酯制成的中空纤维中。该系统作为口服缓释给药系统进行了研究。通过相转化法纺丝纤维，并将其切割成不同的长径比（长度/直径）。采用美国药典篮法来评估体外药物释放动力学以及长径比对释放的影响。为了进行体内评估，将选定的纤维装入明胶胶囊中口服给予犬。与口服速释制剂相比，该纤维给药系统提供了血浆PPA的缓释曲线和更长的终末半衰期。
