Goodson J M, Haffajee A, Socransky S S
J Clin Periodontol. 1979 Apr;6(2):83-92. doi: 10.1111/j.1600-051x.1979.tb02186.x.
The present investigation assessed the feasibility of treating periodontal disease by controlled delivery of antibacterial agents from within periodontal pockets. Tetracycline-filled hollow fibers placed in the gingival sulcus were shown to have a dramatic effect both on the periodontal microflora and clinical manifestations of disease. Furthermore, it was found that drug-filled cellulose acetate hollow fibers are biologically compatible with the environment and can be manipulated by dental personnel to provide drug therapy with less than 1/1000 the amount of tetracycline that would have been used for systemic therapy. Of theoretical importance is the observation that virtual elimination of spirochetes from the gingival sulcus is possible by a single placement of tetracycline-filled hollow fibers, and spirochetes, once eliminated from a site, do not rapidly recolonize despite the persistence of viable organisms elsewhere in the mouth.
本研究评估了通过牙周袋内可控释放抗菌剂治疗牙周疾病的可行性。置于龈沟内的填充四环素的中空纤维对牙周微生物群和疾病的临床表现均显示出显著效果。此外，还发现填充药物的醋酸纤维素中空纤维与周围环境具有生物相容性，并且牙科人员可以对其进行操作，以提供药物治疗，所用四环素量不到全身治疗所需量的千分之一。具有理论重要性的一点观察是，通过单次放置填充四环素的中空纤维，有可能使龈沟内的螺旋体几乎完全消除，而且一旦从某个部位消除，螺旋体不会迅速重新定植，尽管口腔其他部位仍存在活的微生物。
