豚鼠中吗啡-3-β-D-葡萄糖醛酸苷的胎盘通透性

Placental permeability for morphine-3-beta-D-glucuronide in the guinea pig.

作者信息

Olsen G D, Norris S R, Sommer K M, Grosso S M

机构信息

Department of Pharmacology, School of Medicine, Oregon Health Sciences University, Portland 97201.

出版信息

Placenta. 1989 Jan-Feb;10(1):83-93. doi: 10.1016/0143-4004(89)90009-x.

DOI:10.1016/0143-4004(89)90009-x

PMID:2717546

Abstract

The fetal Vd and the PS of the major metabolite of morphine, M3G, were studied in pregnant guinea pigs during the last half of gestation. Fetal Vd was determined to be 0.334 ml/g of fetal plus placental weight and did not vary as the gestation progressed. The mean +/- s.e. PS for M3G was 3.7 +/- 0.3 X 10(-5) ml/sec/g and was independent of anaesthesia. This value was consistent with previous studies of other hydrophilic compounds, indicating that diffusion governs the placental passage of M3G. The PS value increased with increasing fetal weight which was consistent with structural changes in the guinea pig placenta as fetal age progresses in late gestation.

摘要

在妊娠后半期，对怀孕豚鼠体内吗啡主要代谢产物M3G的胎儿分布容积（Vd）和胎盘转运率（PS）进行了研究。胎儿Vd被测定为每克胎儿加胎盘重量0.334毫升，且不随妊娠进展而变化。M3G的平均±标准误PS为3.7±0.3×10⁻⁵毫升/秒/克，且与麻醉无关。该值与先前对其他亲水性化合物的研究一致，表明扩散控制着M3G的胎盘转运。PS值随胎儿体重增加而升高，这与妊娠后期豚鼠胎盘随胎龄进展的结构变化一致。