AtNHX5和AtNHX6：在蛋白质转运中的作用。
AtNHX5 and AtNHX6: Roles in protein transport.
作者信息
Qiu Quan-Sheng
机构信息
a MOE Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University , Lanzhou , Gansu , China.
出版信息
Plant Signal Behav. 2016 Jun 2;11(6):e1184810. doi: 10.1080/15592324.2016.1184810.
AtNHX5 and AtNHX6, endosomal Na(+),K(+)/H(+) antiporters in Arabidopsis, are localized in the Golgi, trans-Golgi network, and prevacuolear compartment. It becomes evident that AtNHX5 and AtNHX6 play an important role in protein transport toward the vacuole. Studies have shown that AtNHX5 and AtNHX6 regulate the transport of seed storage proteins as well as the biogenesis of the protein storage vacuoles. Three distinct mechanisms have been revealed for the roles of AtNHX5 and AtNHX6 in protein transport. AtNHX5 and AtNHX6 control: (i) the binding of VSR to its cargoes; (ii) the recycling of VSRs; and (iii) subcellular localization of the SNARE complex. Moreover, it has been found that the endosomal pH homeostasis maintained by AtNHX5 and AtNHX6 is critical for the transport of seed storage proteins. Taken together, AtNHX5 and AtNHX6 regulate the trafficking of seed storage proteins into the vacuole; the H(+) leak pathway conducted by AtNHX5 and AtNHX6 is critical for protein transport.
拟南芥中的液泡内体Na⁺,K⁺/H⁺逆向转运蛋白AtNHX5和AtNHX6定位于高尔基体、反式高尔基体网络和前液泡区室。很明显，AtNHX5和AtNHX6在蛋白质向液泡的转运中起重要作用。研究表明，AtNHX5和AtNHX6调节种子储存蛋白的转运以及蛋白质储存液泡的生物发生。已揭示AtNHX5和AtNHX6在蛋白质转运中的作用有三种不同机制。AtNHX5和AtNHX6控制：（i）VSR与其货物的结合；（ii）VSR的循环利用；以及（iii）SNARE复合体的亚细胞定位。此外，已发现由AtNHX5和AtNHX6维持的液泡内体pH稳态对于种子储存蛋白的转运至关重要。综上所述，AtNHX5和AtNHX6调节种子储存蛋白向液泡的运输；由AtNHX5和AtNHX6介导的H⁺泄漏途径对于蛋白质运输至关重要。
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