Sun Yueji, Zhang Liang, Ancharaz S Shasheekant, Cheng Sijian, Sun Wenheng, Wang Hongjun, Sun Yan
Dalian Medical University, Neuropsychological department, Liaoning Province, China.
Dalian Medical University, Neuropsychological department, Liaoning Province, China.
Behav Brain Res. 2016 Sep 1;310:68-75. doi: 10.1016/j.bbr.2016.05.022. Epub 2016 May 10.
To find a difference in fractional anisotropy (FA) between young adult males with schizotypal personality disorder (SPD) and healthy controls (HCs).
Sixteen males with SPD and sixteen HCs were selected from 3500 freshmen across two universities. The 32 participants were evaluated by the Minnesota Multiphasic Personality Inventory (MMPI) (Chinese Version Sc≥70) and the Schizotypal Personality Questionnaire (SPQ). Structured diagnostic interview was carried out and all the subjects in the SPD group met DSM-IV diagnostic criteria for SPD. All participants underwent brain magnetic resonance imaging, and their diffusion tensor imaging (DTI) data was collected. DTI data was analysed using tract-based spatial statistics (TBSS), and the neurofibre connection from the hippocampus to the right entorhinal cortex was traced. Informed consent was obtained from all participants.
(1) SPD and HCs had a significant difference in SPQ symptoms (P<0.05). (2) There was a significant difference in the fractional anisotropy of two clusters of the brain between the two groups (P<0.05). The first cluster included the right pallidum, right retro-lenticular part of the internal capsule, right inferior longitudinal fasciculus (rILF), right posterior parietal lobe, right temporal lobe and right occipital lobe. The second cluster included the right hippocampus, right fornix, and right temporal lobe. (3) FA volume in the rILF positively correlated with scores related to the "lack of friends" subscale of the SPQ.
These results suggest reduced white matter in two brain clusters of young adult males with SPD. These findings are similar to previous reports on patients experiencing their first schizophrenic episode.
探究分裂型人格障碍（SPD）的青年男性与健康对照者（HCs）之间的分数各向异性（FA）差异。
从两所大学的3500名新生中选取16名患有SPD的男性和16名HCs。32名参与者接受了明尼苏达多相人格调查表（MMPI）（中文版Sc≥70）和分裂型人格问卷（SPQ）评估。进行了结构化诊断访谈，SPD组的所有受试者均符合SPD的DSM-IV诊断标准。所有参与者均接受了脑磁共振成像，并收集了他们的扩散张量成像（DTI）数据。使用基于纤维束的空间统计学（TBSS）分析DTI数据，并追踪从海马体到右侧内嗅皮质的神经纤维连接。所有参与者均获得了知情同意。
（1）SPD组和HCs组在SPQ症状方面存在显著差异（P<0.05）。（2）两组之间大脑的两个簇的分数各向异性存在显著差异（P<0.05）。第一个簇包括右侧苍白球、右侧内囊后豆状核部、右侧下纵束（rILF）、右侧顶叶后部、右侧颞叶和右侧枕叶。第二个簇包括右侧海马体、右侧穹窿和右侧颞叶。（3）rILF中的FA体积与SPQ中“缺乏朋友”子量表相关的得分呈正相关。
这些结果表明，患有SPD的青年男性大脑中的两个簇的白质减少。这些发现与先前关于首次发作精神分裂症患者的报道相似。
