Scherer T, Kieser C, Gerber H
Ther Umsch. 1989 Apr;46(4):258-64.
This is a follow up study of 110 patients referred to the hospital because of mono-arthritis of unknown etiology. Patients with mechanical synovitis and infectious arthritis have been excluded from this study initially. From a total of 110 patients (100%) a diagnosis could be made in 49 patients (44.6%), namely in 24 (21.8%) by the initial very thorough work up or by the repeated examinations during the follow up period in 25 patients (22.8%). In 61 patients (55.4%) the cause of the disease remained unknown despite extensive investigations and follow up controls for many years. Of these 61 cases three (2.7%) developed polyarthritis and six (5.5%) oligoarthritis still of unknown origin. The rest, namely 52 (47.2%) remained mono-arthritis and are called mono-arthritis of unknown origin ("Arthritis unbekannter Ursache"). 67% of these 52 patients with mono-arthritis of unknown origin went into complete remission after one year and 80% after two years. 13 patients (11.8%) of the 110 developed rheumatoid arthritis within one month up to three years. Arthroscopy was important in making some diagnosis initially. Twelve patients had relief of symptoms after arthroscopy, ten of the group with mono-arthritis of unknown origin. 19 patients claimed that the initiating factor was a trauma to the joint.
这是一项对110例因不明病因单关节炎而转诊至该医院的患者的随访研究。机械性滑膜炎和感染性关节炎患者最初被排除在本研究之外。在总共110例患者（100%）中，49例患者（44.6%）得以确诊，其中24例（21.8%）通过最初非常全面的检查确诊，25例（22.8%）在随访期间通过反复检查确诊。尽管进行了多年的广泛调查和随访对照，仍有61例患者（55.4%）病因不明。在这61例病例中，3例（2.7%）发展为多关节炎，6例（5.5%）发展为少关节炎，病因仍不明。其余52例（47.2%）仍为单关节炎，被称为不明原因单关节炎（“Arthritis unbekannter Ursache”）。这52例不明原因单关节炎患者中，67%在1年后完全缓解，80%在2年后完全缓解。110例患者中有13例（11.8%）在1个月至3年内发展为类风湿关节炎。关节镜检查在最初的一些诊断中很重要。12例患者在关节镜检查后症状缓解，其中10例来自不明原因单关节炎组。19例患者称发病因素为关节创伤。
