Adachi Tadashi, Yasui Kenichi, Takahashi Toshiyuki, Fujihara Kazuo, Watanabe Yasuhiro, Nakashima Kenji
Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Japan.
Intern Med. 2016;55(10):1351-4. doi: 10.2169/internalmedicine.55.6122. Epub 2016 May 15.
We herein report a case of recurrent optic neuritis involving the cerebral white matter and brainstem in a patient positive for anti-myelin oligodendrocyte glycoprotein (MOG) antibodies. The patient had an initial attack at 24 years of age. Optic neuritis recurred over 14 years, and she was admitted to our neurology unit at 38 years of age. She showed bilateral optic neuritis, high-intensity lesions in the cerebral white matter and brainstem on T2 MRI with contrast enhancement, and elevated serum anti-MOG antibodies. Immunotherapy improved the MRI lesions. Recurrent optic neuritis in patients with anti-MOG antibodies may thus involve the cerebral white matter and brainstem.
我们在此报告一例抗髓鞘少突胶质细胞糖蛋白（MOG）抗体阳性患者出现复发性视神经炎，累及脑白质和脑干。该患者24岁时首次发病。视神经炎在14年间反复发作，38岁时入住我们的神经内科病房。她表现为双侧视神经炎，T2加权磁共振成像（MRI）显示脑白质和脑干有高强度病变且有对比增强，血清抗MOG抗体升高。免疫治疗改善了MRI病变。因此，抗MOG抗体阳性患者的复发性视神经炎可能累及脑白质和脑干。
