Jafar J J, Menoni R, Feinberg H, LeBreton G, Crowell R M
Department of Neurosurgery, University of Illinois, Chicago.
Stroke. 1989 May;20(5):664-7. doi: 10.1161/01.str.20.5.664.
Platelet deposition in the microcirculation may play a role in focal cerebral ischemia. We investigated platelet deposition in selected parts of the cat brain after temporary middle cerebral artery occlusion. Ten anesthesized cats were given autologous indium-111-labeled platelets and chromium-51-labeled erythrocytes. The right middle cerebral artery was occluded with miniature aneurysm clips for 3 hours via a transorbital approach; blood pressure was reduced concomitantly to decrease the collateral circulation. Removal of the clips initiated a 45-minute period of normotensive reperfusion. After sacrifice, the brain was removed and sectioned for comparison of right- versus left-hemisphere platelet deposition. Platelets were selectively deposited in the territory of the occluded right middle cerebral artery. Significant deposition was found in the caudate nucleus, internal capsule, parietal cortex, and the centrum semiovale. Our findings support the evidence that platelets are deposited in the microvasculature during temporary severe focal cerebral ischemia.
血小板在微循环中的沉积可能在局灶性脑缺血中起作用。我们研究了猫大脑中动脉暂时闭塞后选定部位的血小板沉积情况。十只麻醉猫被注入自体铟 - 111标记的血小板和铬 - 51标记的红细胞。通过经眶入路，用微型动脉瘤夹将右侧大脑中动脉闭塞3小时；同时降低血压以减少侧支循环。移除夹子后开始45分钟的正常血压再灌注期。处死后，取出大脑并切片以比较左右半球的血小板沉积情况。血小板选择性地沉积在闭塞的右侧大脑中动脉区域。在尾状核、内囊、顶叶皮质和半卵圆中心发现了显著的沉积。我们的研究结果支持了在短暂严重局灶性脑缺血期间血小板沉积在微血管系统中的证据。
