Sundin George W, Wang Nian, Charkowski Amy O, Castiblanco Luisa F, Jia Hongge, Zhao Youfu
First and fourth authors: Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing; second and fifth authors: Citrus Research and Education Center, Department of Microbiology and Cell Science, Institute of Food and Agricultural Science, University of Florida, Lake Alfred; third author: Department of Plant Pathology, University of Wisconsin-Madison; sixth author: Department of Crop Sciences, University of Illinois at Urbana-Champaign.
Phytopathology. 2016 Oct;106(10):1071-1082. doi: 10.1094/PHYTO-03-16-0117-FI. Epub 2016 Jul 19.
The advent of genomics has advanced science into a new era, providing a plethora of "toys" for researchers in many related and disparate fields. Genomics has also spawned many new fields, including proteomics and metabolomics, furthering our ability to gain a more comprehensive view of individual organisms and of interacting organisms. Genomic information of both bacterial pathogens and their hosts has provided the critical starting point in understanding the molecular bases of how pathogens disrupt host cells to cause disease. In addition, knowledge of the complete genome sequence of the pathogen provides a potentially broad slate of targets for the development of novel virulence inhibitors that are desperately needed for disease management. Regarding plant bacterial pathogens and disease management, the potential for utilizing genomics resources in the development of durable resistance is enhanced because of developing technologies that enable targeted modification of the host. Here, we summarize the role of genomics studies in furthering efforts to manage bacterial plant diseases and highlight novel genomics-enabled strategies heading down this path.
基因组学的出现将科学推进到了一个新时代，为许多相关和不同领域的研究人员提供了大量“工具”。基因组学还催生了许多新领域，包括蛋白质组学和代谢组学，进一步提升了我们对个体生物以及相互作用生物的全面认识能力。细菌病原体及其宿主的基因组信息为理解病原体如何破坏宿主细胞导致疾病的分子基础提供了关键的起点。此外，病原体完整基因组序列的知识为开发新型毒力抑制剂提供了一系列潜在的广泛靶点，而这些抑制剂对于疾病管理来说是迫切需要的。关于植物细菌病原体和疾病管理，由于能够对宿主进行靶向修饰的技术不断发展，利用基因组学资源开发持久抗性的潜力得到了增强。在此，我们总结了基因组学研究在推动植物细菌性病害管理工作中的作用，并强调了沿着这条道路发展的新型基因组学策略。
