Équipe d'accueil « Modélisation de l'agression tissulaire et nociceptive », Toulouse University Teaching Hospital, Université Toulouse III Paul-Sabatier, Hôpital Pierre-Paul-Riquet, CHU de Toulouse, place du Dr-Baylac, 31059 Toulouse cedex 09, France.
Équipe d'accueil « Modélisation de l'agression tissulaire et nociceptive », Toulouse University Teaching Hospital, Université Toulouse III Paul-Sabatier, Hôpital Pierre-Paul-Riquet, CHU de Toulouse, place du Dr-Baylac, 31059 Toulouse cedex 09, France.
Anaesth Crit Care Pain Med. 2016 Oct;35(5):355-361. doi: 10.1016/j.accpm.2016.05.001. Epub 2016 May 13.
Hypothermia, along with acidosis and coagulopathy, is part of the lethal triad that worsen the prognosis of severe trauma patients. While accidental hypothermia is easy to identify by a simple measurement, it is no less pernicious if it is not detected or treated in the initial phase of patient care. It is a multifactorial process and is a factor of mortality in severe trauma cases. The consequences of hypothermia are many: it modifies myocardial contractions and may induce arrhythmias; it contributes to trauma-induced coagulopathy; from an immunological point of view, it diminishes inflammatory response and increases the chance of pneumonia in the patient; it inhibits the elimination of anaesthetic drugs and can complicate the calculation of dosing requirements; and it leads to an over-estimation of coagulation factor activities. This review will detail the pathophysiological consequences of hypothermia, as well as the most recent principle recommendations in dealing with it.
低体温与酸中毒和凝血功能障碍一起构成了致死三联征,使严重创伤患者的预后恶化。虽然意外低体温通过简单的测量很容易识别,但如果在患者护理的初始阶段未被发现或治疗,其危害同样不容小觑。这是一个多因素的过程,也是严重创伤病例死亡的一个因素。低体温的后果很多:它会改变心肌收缩并可能引发心律失常;它会导致创伤性凝血功能障碍;从免疫学角度来看,它会减弱炎症反应并增加患者肺炎的机会;它会抑制麻醉药物的清除,并使麻醉药物剂量计算复杂化;它还会导致凝血因子活性的高估。本篇综述将详细阐述低体温的病理生理学后果,以及处理低体温的最新原则建议。