环糊精类型依赖性主体-客体相互作用模式与酞菁及其对癌症光动力活性的影响。
Cyclodextrin type dependent host-guest interaction mode with phthalocyanine and their influence on photodynamic activity to cancer.
机构信息
College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
出版信息
Carbohydr Polym. 2016 Sep 5;148:236-42. doi: 10.1016/j.carbpol.2016.04.062. Epub 2016 Apr 16.
Three host-guest complexes of phthalocyanines (Pc) with α-, β- or γ-cyclodextrins (CDs) were prepared and their interaction modes, reactive oxygen species (ROSs) generation ability and in vitro anticancer activities were studied and compared. After forming complex with CD, the aggregation degree of Pc was greatly decreased and the water solubility and photodynamic activity was sharply increased. Computer modeling results indicated that the interaction modes between Pc and CDs were varied with different kinds of CD. Especially, the complex of Pc and β-CD has superior stability, ROSs generation ability, and anticancer activity to other complexes.
三种酞菁（Pc）与α-、β-或γ-环糊精（CD）的主体客体配合物被制备，并对其相互作用模式、活性氧（ROS）生成能力和体外抗癌活性进行了研究和比较。与 CD 形成配合物后，Pc 的聚集程度大大降低，水溶性和光动力活性显著提高。计算机建模结果表明，Pc 与 CDs 的相互作用模式随 CD 的种类而变化。特别是，Pc 和β-CD 的配合物具有优于其他配合物的稳定性、ROS 生成能力和抗癌活性。
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