[抗心律失常药物重酒石酸丙吡胺对体内血液凝固的影响]
[Modification of blood coagulation by the anti-arrhythmia drug prajmalium bitartrate in vivo].
作者信息
Riess H, Bauer F, Hoffmann E, Steinbeck G, Hiller E
机构信息
Medizinische Kliniken III, Ludwig-Maximilians-Universität, München.
出版信息
Z Kardiol. 1989 Feb;78(2):130-3.
We studied the effects of prajmaliumbitartrate (PBT, Neo-Gilurytmal, Giulini Pharma, Hannover, FRG), an antiarrhythmic drug on some parameters of blood coagulation in patients. PBT, 20 mg given three times a day, significantly prolonged template bleeding time and ex vivo thrombus formation time in a modified Chandler's loop. Ex vivo platelet aggregation using different agonists and tests of the plasmatic coagulation system remained unchanged.
我们研究了抗心律失常药物普拉马林酒石酸盐（PBT，商品名Neo-Gilurytmal，由德国汉诺威的朱利尼制药公司生产）对患者某些凝血参数的影响。PBT剂量为每日三次，每次20毫克，可显著延长改良钱德勒环路法中的模板出血时间和体外血栓形成时间。使用不同激动剂进行的体外血小板聚集试验以及血浆凝血系统检测结果均未改变。
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