利多卡因的神经保护作用：是否具有临床潜力？
Neuroprotective effect of lidocaine: is there clinical potential?
作者信息
Leng Tiandong, Gao Xiuren, Dilger James P, Lin Jun
机构信息
Neuroscience Institute, Morehouse School of Medicine Atlanta, GA 30310, USA.
Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University Guangzhou, Guangdong 510080, P.R. China.
出版信息
Int J Physiol Pathophysiol Pharmacol. 2016 Apr 25;8(1):9-13. eCollection 2016.
Abstract
Local anesthetic lidocaine has been shown to be protective in animal models of focal and global ischemia as well as in in vitro hypoxic models. Lidocaine has been tested in patients for its potential protective effect on postoperative cognitive dysfunction. This mini-review summarizes the laboratory and clinical evidences and discusses its clinical applications as neuroprotective agent.
摘要
局部麻醉药利多卡因已被证明在局灶性和全脑缺血动物模型以及体外缺氧模型中具有保护作用。利多卡因已在患者中进行测试，以评估其对术后认知功能障碍的潜在保护作用。本综述总结了实验室和临床证据，并讨论了其作为神经保护剂的临床应用。
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