Traystman Richard J
Department of Anesthesiology/Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
ILAR J. 2003;44(2):85-95. doi: 10.1093/ilar.44.2.85.
The use of appropriate animal models is essential to predict the value and effect of therapeutic approaches in human subjects. Focal (stroke) and global (cardiac arrest) cerebral ischemia represents diseases that are common in the human population. Stroke and cardiac arrest, which are major causes of death and disability, affect millions of individuals around the world and are responsible for the leading health care costs of all diseases. Understanding the mechanisms of injury and neuroprotection in these diseases is critical if we are ever to learn new target sites to treat ischemia. There are many animal models available to investigate injury mechanisms and neuroprotective strategies. This review summarizes many (but not all) small and large animal models of focal and global cerebral ischemia and discusses their advantages and disadvantages.
使用合适的动物模型对于预测治疗方法在人类受试者中的价值和效果至关重要。局灶性（中风）和全脑性（心脏骤停）脑缺血是人类常见的疾病。中风和心脏骤停是导致死亡和残疾的主要原因，影响着全球数百万人，并且是所有疾病中主要的医疗费用负担。如果我们想要找到治疗缺血的新靶点，了解这些疾病中的损伤机制和神经保护作用至关重要。有许多动物模型可用于研究损伤机制和神经保护策略。本综述总结了许多（但不是全部）局灶性和全脑性脑缺血的小型和大型动物模型，并讨论了它们的优缺点。
