Blagosklonova N K
Zh Nevropatol Psikhiatr Im S S Korsakova. 1989;89(1):112-6.
The study deals with the influence of therapy with chlorpromazine on EEG in children aged 9 to 15 with psychopath-like affective-excitable behavior of residual-organic origin (21 patients, and with pathologic personality development of affective-excitable type (15 patients). Baseline indices of the brain electric activity were compared with those during chlorpromazine treatment. Histographic analysis was applied to EEG. The rate of extinction of various components of orienting response to sound (activation response, vertex-potential, galvanic skin response) were also recorded, as was the reproduction of the rhythm of light flashed at different rates. The results pointed to the increase in pathological signs in the patients' EEG during the prolonged chlorpromazine course that suggested its more careful use in children with psychopath-like affective-excitable behavior.
该研究探讨了氯丙嗪治疗对9至15岁患有残留器质性病因的类精神病性情感易激行为儿童（21例）以及情感易激型病理性人格发展儿童（15例）脑电图的影响。将脑电活动的基线指标与氯丙嗪治疗期间的指标进行比较。对脑电图进行了直方图分析。还记录了对声音定向反应的各种成分（激活反应、顶点电位、皮肤电反应）的消退率，以及不同频率闪烁光节律的再现情况。结果表明，在长期使用氯丙嗪的过程中，患者脑电图中的病理征象增多，这提示在患有类精神病性情感易激行为的儿童中应更谨慎地使用该药。
