Faculty of Chemistry, Institute of Organic Chemistry, University of Vienna , Währinger Strasse 38, 1090 Vienna, Austria.
J Org Chem. 2016 Jun 3;81(11):4421-8. doi: 10.1021/acs.joc.6b00675. Epub 2016 May 17.
The electrophilic activation of amides, especially by the action of trifluoromethanesulfonic (triflic) anhydride, enables the formation of highly electrophilic and reactive intermediates, lending themselves to diverse reaction pathways. This synopsis sets out to highlight recent advances in the field of amide activation, focused on the use of triflic anhydride, and the myriad of transformations that can ensue upon addition of several classes of electrophiles to the intermittently generated high energy intermediates.
酰胺的亲电活化，特别是通过三氟甲磺酸（三氟甲磺酸）酐的作用，能够形成高亲电和高反应性的中间体，从而使其适合多种反应途径。这篇综述旨在强调酰胺活化领域的最新进展，重点是使用三氟甲磺酸酐，以及在间歇性生成的高能中间体中加入几类亲电试剂后可能发生的多种转化。
