Cui J, Guo X M, Bao H L, Tan J B
National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2016 May;37(5):725-9. doi: 10.3760/cma.j.issn.0254-6450.2016.05.029.
To analyze the relationship between N-nitrosodimethylamine(NDMA)and the risk of digestive tract cancers.
The papers about the relationship between NDMA and the risk of digestive tract cancers published from 1980 to 2012 were retrieved following databases: Chinese BioMedical Literature Database(CBM), the Chinese Journal Full-text Database(CNKI), Wanfang Database, PubMed and EBSCO. The fix and random effect model was used and statistical analyses were conducted by using RevMan 5.1 software.
Thirteen papers were found, in which 7 about digestive tract cancers were used in this Meta analysis. The NDMA had significant positive effect on the incidence of digestive tract cancers(RR=1.12, 95% CI: 1.03-1.21). The relationship between NDMA and esophageal cancer was not significant(RR=1.18, 95%CI: 0.98-1.41)but NDMA could increase the risk of gastric cancer(RR=1.08, 95% CI: 1.00-1.18). For the subtypes of esophageal and gastric cancer, NDMA had positive relationship with esophageal squamous cell carcinoma(RR=1.72, 95% CI: 1.01-2.96), but had no significant relationship with esophageal adenocarcinoma, cardiac carcinoma and gastric adenocarcinoma.
The population-based cohort studies have showed that the NDMA could significantly increase the risk of digestive tract cancers, but the effects differed with subtypes of esophageal and gastric cancer. However, it is necessary to collect more evidence due to the limited studies and obvious differences in the study design, sampling and exposure measurement of these cohort studies.
分析N-亚硝基二甲胺（NDMA）与消化道癌症风险之间的关系。
检索1980年至2012年发表的关于NDMA与消化道癌症风险关系的文献，检索数据库如下：中国生物医学文献数据库（CBM）、中国期刊全文数据库（CNKI）、万方数据库、PubMed和EBSCO。采用固定效应模型和随机效应模型，使用RevMan 5.1软件进行统计分析。
共检索到13篇文献，其中7篇关于消化道癌症的文献纳入本Meta分析。NDMA对消化道癌症的发病率有显著的正向影响（RR=1.12，95%CI：1.03-1.21）。NDMA与食管癌的关系不显著（RR=1.18，95%CI：0.98-1.41），但NDMA可增加胃癌风险（RR=1.08，95%CI：1.00-1.18）。对于食管癌和胃癌的亚型，NDMA与食管鳞状细胞癌呈正相关（RR=1.72，95%CI：1.01-2.96），但与食管腺癌、贲门癌和胃腺癌无显著关系。
基于人群的队列研究表明，NDMA可显著增加消化道癌症的风险，但对食管癌和胃癌亚型的影响有所不同。然而，由于这些队列研究的样本量有限，且在研究设计、抽样和暴露测量方面存在明显差异，因此有必要收集更多证据。
