传统草药治疗非酒精性脂肪性肝病的荟萃分析。
Meta-analysis of traditional herbal medicine in the treatment of nonalcoholic fatty liver disease.
作者信息
Peng H, He Y, Zheng G, Zhang W, Yao Z, Xie W
机构信息
Changhai Hospital, the Second Military Medical University Department of Traditional Chinese Medicine Shanghai China.
Changhai Hospital, the Second Military Medical University Department of Traditional Chinese Medicine Shanghai China
出版信息
Cell Mol Biol (Noisy-le-grand). 2016 Apr 30;62(4):88-95.
Traditional Chinese herbal medicine (TCM) has been found effective for nonalcoholic fatty liver disease (NAFLD) based on its unique theory system and substantial herb remedies. The aim of this meta-analysis was to evaluate the efficiency and safety of one of the TCM, Danshen in the treatment of NAFLD. Seven English and Chinese databases were searched from inceptions to December 2015. RCTs which compared Danshen with placebo in adult patients with NAFLD were included. Totally, 8 RCTs with a total of 800 patients were identified. The results showed that compared with placebo, Danshen had increased total effectiveness rate, lower level of ALT, AST, TC and TG, LDL and higher level of liver/spleen computed tomography ratio. The present meta-analysis suggests that Danshen may have positive effects on nonalcoholic fatty liver disease. Future multicenter large-sample randomized clinical trials are still needed to confirm the efficacy and safety of our study.
基于其独特的理论体系和丰富的草药疗法，传统中药已被发现对非酒精性脂肪性肝病（NAFLD）有效。本荟萃分析的目的是评估中药丹参治疗NAFLD的有效性和安全性。检索了7个中英文数据库，时间跨度从建库至2015年12月。纳入了在成年NAFLD患者中将丹参与安慰剂进行比较的随机对照试验（RCT）。共识别出8项RCT，涉及800名患者。结果显示，与安慰剂相比，丹参提高了总有效率，降低了谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）水平，并提高了肝脏/脾脏计算机断层扫描比值。本荟萃分析表明，丹参可能对非酒精性脂肪性肝病有积极作用。未来仍需要多中心大样本随机临床试验来证实本研究的疗效和安全性。
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