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农民抑郁症状与全因死亡率的队列研究:挪威HUNT研究

Symptoms of depression and all-cause mortality in farmers, a cohort study: the HUNT study, Norway.

作者信息

Letnes Jon Magne, Torske Magnhild Oust, Hilt Bjørn, Bjørngaard Johan Håkon, Krokstad Steinar

机构信息

Norwegian University of Science and Technology, NTNU, Trondheim, Norway.

HUNT Research Centre, Department of Public Health and General Practice, Faculty of Medicine, the Norwegian University of Science and Technology (NTNU), Levanger, Norway.

出版信息

BMJ Open. 2016 May 17;6(5):e010783. doi: 10.1136/bmjopen-2015-010783.

Abstract

OBJECTIVES

To explore all-cause mortality and the association between symptoms of depression and all-cause mortality in farmers compared with other occupational groups, using a prospective cohort design.

METHODS

We included adult participants with a known occupation from the second wave of the Nord-Trøndelag Health Study (Helseundersøkelsen i Nord-Trøndelag 2 (HUNT2) 1995-1997), Norway. Complete information on emigration and death from all causes was obtained from the National Registries. We used the depression subscale of the Hospital Anxiety and Depression Scale (HADS) to measure symptoms of depression. We compared farmers to 4 other occupational groups. Our baseline study population comprised 32 618 participants. Statistical analyses were performed using the Cox proportional hazards models.

RESULTS

The estimated mortality risk in farmers was lower than in all other occupations combined, with a sex and age-adjusted HR (0.91, 95% CI 0.82 to 1.00). However, farmers had an 11% increased age-adjusted and sex-adjusted mortality risk compared with the highest ranked socioeconomic group (HR 1.11, 95% CI 0.98 to 1.25). In farmers, symptoms of depression were associated with a 13% increase in sex-adjusted and age-adjusted mortality risk (HR 1.13, 95% CI 0.88 to 1.45). Compared with other occupations this was the lowest HR, also after adjusting for education, marital status, long-lasting limiting somatic illness and lifestyle factors (HR 1.08, 95% CI 0.84 to 1.39).

CONCLUSIONS

Farmers had lower all-cause mortality compared with the other occupational groups combined. Symptoms of depression were associated with an increased mortality risk in farmers, but the risk increase was smaller compared with the other occupational groups.

摘要

目的

采用前瞻性队列设计,探讨与其他职业群体相比,农民的全因死亡率以及抑郁症状与全因死亡率之间的关联。

方法

我们纳入了来自挪威北特伦德拉格健康研究第二轮(1995 - 1997年北特伦德拉格健康调查2,简称HUNT2)中已知职业的成年参与者。从国家登记处获取了关于移民和全因死亡的完整信息。我们使用医院焦虑抑郁量表(HADS)的抑郁分量表来测量抑郁症状。我们将农民与其他4个职业群体进行比较。我们的基线研究人群包括32618名参与者。使用Cox比例风险模型进行统计分析。

结果

农民的估计死亡风险低于所有其他职业群体之和,经性别和年龄调整后的风险比(HR)为0.91,95%置信区间为0.82至1.00。然而,与社会经济地位最高的群体相比,农民经年龄和性别调整后的死亡风险增加了11%(HR 1.11,95%置信区间为0.98至1.25)。在农民中,抑郁症状与经性别和年龄调整后的死亡风险增加13%相关(HR 1.13,95%置信区间为0.88至1.45)。与其他职业相比,这是最低的风险比,在调整教育程度、婚姻状况、长期限制身体疾病和生活方式因素后也是如此(HR 1.08,95%置信区间为0.84至1.39)。

结论

与其他职业群体之和相比,农民的全因死亡率较低。抑郁症状与农民的死亡风险增加相关,但与其他职业群体相比,风险增加幅度较小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/893a/4874135/bf94479a11d9/bmjopen2015010783f01.jpg

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