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基于完整蒙特卡罗方法和测量的、对改进的电子密度蒙特卡罗(eMC)算法临床实施的整体性能评估,重点关注较低能量范围。

Full Monte Carlo and measurement-based overall performance assessment of improved clinical implementation of eMC algorithm with emphasis on lower energy range.

作者信息

Ojala Jarkko, Kapanen Mika, Hyödynmaa Simo

机构信息

Department of Oncology, Unit of Radiotherapy, Tampere University Hospital, P.O. Box 2000, FI-33521 Tampere, Finland; Department of Medical Physics, Medical Imaging Center, Tampere University Hospital, P.O. Box 2000, FI-33521 Tampere, Finland.

Department of Medical Physics, Medical Imaging Center, Tampere University Hospital, P.O. Box 2000, FI-33521 Tampere, Finland.

出版信息

Phys Med. 2016 Jun;32(6):801-11. doi: 10.1016/j.ejmp.2016.05.005. Epub 2016 May 14.

Abstract

New version 13.6.23 of the electron Monte Carlo (eMC) algorithm in Varian Eclipse™ treatment planning system has a model for 4MeV electron beam and some general improvements for dose calculation. This study provides the first overall accuracy assessment of this algorithm against full Monte Carlo (MC) simulations for electron beams from 4MeV to 16MeV with most emphasis on the lower energy range. Beams in a homogeneous water phantom and clinical treatment plans were investigated including measurements in the water phantom. Two different material sets were used with full MC: (1) the one applied in the eMC algorithm and (2) the one included in the Eclipse™ for other algorithms. The results of clinical treatment plans were also compared to those of the older eMC version 11.0.31. In the water phantom the dose differences against the full MC were mostly less than 3% with distance-to-agreement (DTA) values within 2mm. Larger discrepancies were obtained in build-up regions, at depths near the maximum electron ranges and with small apertures. For the clinical treatment plans the overall dose differences were mostly within 3% or 2mm with the first material set. Larger differences were observed for a large 4MeV beam entering curved patient surface with extended SSD and also in regions of large dose gradients. Still the DTA values were within 3mm. The discrepancies between the eMC and the full MC were generally larger for the second material set. The version 11.0.31 performed always inferiorly, when compared to the 13.6.23.

摘要

瓦里安 Eclipse™ 治疗计划系统中电子蒙特卡洛(eMC)算法的新版本 13.6.23 具有 4MeV 电子束模型,并在剂量计算方面有一些总体改进。本研究首次针对 4MeV 至 16MeV 的电子束,以全蒙特卡洛(MC)模拟为对照,对该算法进行了全面的精度评估,重点关注较低能量范围。研究了均匀水模体中的射束以及临床治疗计划,包括在水模体中的测量。全 MC 使用了两种不同的材料集:(1)eMC 算法中应用的材料集,(2)Eclipse™ 中其他算法所包含的材料集。临床治疗计划的结果也与旧版本 eMC 11.0.31 的结果进行了比较。在水模体中,与全 MC 相比的剂量差异大多小于 3%,距离一致性(DTA)值在 2mm 以内。在剂量建成区、接近最大电子射程的深度以及小孔径情况下,获得了较大的差异。对于临床治疗计划,使用第一种材料集时,总体剂量差异大多在 3% 或 2mm 以内。对于大 4MeV 射束进入弯曲患者表面且源皮距延长的情况以及大剂量梯度区域,观察到了较大差异。不过 DTA 值仍在 3mm 以内。对于第二种材料集,eMC 与全 MC 之间的差异通常更大。与 13.6.23 相比,11.0.31 版本的表现总是较差。

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