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髋臼唇撕裂的经济影响:一项针对无骨关节炎患者的成本效益分析,比较单纯髋关节镜手术与结构化康复治疗

The Economic Impact of Acetabular Labral Tears: A Cost-effectiveness Analysis Comparing Hip Arthroscopic Surgery and Structured Rehabilitation Alone in Patients Without Osteoarthritis.

作者信息

Lodhia Parth, Gui Chengcheng, Chandrasekaran Sivashankar, Suarez-Ahedo Carlos, Dirschl Douglas R, Domb Benjamin G

机构信息

American Hip Institute, Westmont, Illinois, USA.

The University of Chicago Medicine, Chicago, Illinois, USA.

出版信息

Am J Sports Med. 2016 Jul;44(7):1771-80. doi: 10.1177/0363546516645532. Epub 2016 May 17.

DOI:10.1177/0363546516645532
PMID:27190068
Abstract

BACKGROUND

Hip arthroscopic surgery has emerged as a successful procedure to manage acetabular labral tears and concurrent hip injuries, which if left untreated, may contribute to hip osteoarthritis (OA). Therefore, it is essential to analyze the economic impact of this treatment option.

PURPOSE

To investigate the cost-effectiveness of hip arthroscopic surgery versus structured rehabilitation alone for acetabular labral tears, to examine the effects of age on cost-effectiveness, and to estimate the rate of symptomatic OA and total hip arthroplasty (THA) in both treatment arms over a lifetime horizon.

STUDY DESIGN

Economic and decision analysis; Level of evidence, 2.

METHODS

A cost-effectiveness analysis of hip arthroscopic surgery compared with structured rehabilitation for symptomatic labral tears was performed using a Markov decision model constructed over a lifetime horizon. It was assumed that patients did not have OA. Direct costs (in 2014 United States dollars), utilities of health states (in quality-adjusted life years [QALYs] gained), and probabilities of transitioning between health states were estimated from a comprehensive literature review. Costs were estimated using national averages of Medicare reimbursements, adjusted for all payers in the United States from a societal perspective. Utilities were estimated from the Harris Hip Score. Cost-effectiveness was assessed using the incremental cost-effectiveness ratio (ICER). One-way and probabilistic sensitivity analyses were performed to determine the effect of uncertainty on the model outcomes.

RESULTS

For a cohort representative of patients undergoing hip arthroscopic surgery at our facility, arthroscopic surgery was more costly (additional $2653) but generated more utility (additional 3.94 QALYs) compared with rehabilitation over a lifetime. The mean ICER was $754/QALY, well below the conventional willingness to pay of $50,000/QALY. Arthroscopic surgery was cost-effective for 94.5% of patients. Although arthroscopic surgery decreased in cost-effectiveness with increasing age, arthroscopic surgery remained more cost-effective than rehabilitation for patients in the second to seventh decades of life. The lifetime incidence of symptomatic hip OA was over twice as high for patients treated with rehabilitation compared with arthroscopic surgery. The preferred treatment was sensitive to the utility after successful hip arthroscopic surgery, although the utility at which arthroscopic surgery becomes less cost-effective than rehabilitation is far below our best estimate. For older patients, the lifetime cost of arthroscopic surgery was greater, while the lifetime utility of arthroscopic surgery was less, approaching that of the rehabilitation arm.

CONCLUSION

Hip arthroscopic surgery is more cost-effective and results in a considerably lower incidence of symptomatic OA than structured rehabilitation alone in treating symptomatic labral tears of patients in the second to seventh decades of life without pre-existing OA.

摘要

背景

髋关节镜手术已成为治疗髋臼盂唇撕裂及并发髋关节损伤的一种成功方法,若不治疗,这些损伤可能会导致髋关节骨关节炎(OA)。因此,分析这种治疗方案的经济影响至关重要。

目的

研究髋关节镜手术与单纯结构化康复治疗髋臼盂唇撕裂的成本效益,探讨年龄对成本效益的影响,并估计在整个生命周期内两个治疗组出现症状性OA和全髋关节置换术(THA)的发生率。

研究设计

经济与决策分析;证据等级,2级。

方法

采用基于整个生命周期构建的马尔可夫决策模型,对髋关节镜手术与针对有症状盂唇撕裂的结构化康复治疗进行成本效益分析。假设患者无OA。通过全面的文献综述估计直接成本(以2014年美元计)、健康状态效用(以获得的质量调整生命年[QALY]计)以及健康状态之间转换的概率。成本使用医疗保险报销的全国平均水平进行估计,并从社会角度针对美国所有支付方进行调整。效用根据Harris髋关节评分进行估计。使用增量成本效益比(ICER)评估成本效益。进行单因素和概率敏感性分析以确定不确定性对模型结果的影响。

结果

对于在我们机构接受髋关节镜手术的具有代表性的患者队列,与终身康复相比,关节镜手术成本更高(额外2653美元),但产生的效用更多(额外3.94 QALY)。平均ICER为754美元/QALY,远低于传统的支付意愿50,000美元/QALY。关节镜手术对94.5%的患者具有成本效益。尽管关节镜手术的成本效益随着年龄增长而降低,但对于二三十岁至七十岁的患者,关节镜手术仍然比康复治疗更具成本效益。接受康复治疗的患者出现症状性髋关节OA的终身发生率是接受关节镜手术患者的两倍多。尽管成功进行髋关节镜手术后的效用远低于我们的最佳估计,但关节镜手术比康复治疗更具成本效益的效用阈值,首选治疗对其较为敏感。对于老年患者,关节镜手术的终身成本更高,而关节镜手术的终身效用更低,接近康复治疗组。

结论

在治疗二三十岁至七十岁且无既往OA的有症状盂唇撕裂患者时,髋关节镜手术比单纯结构化康复更具成本效益,且症状性OA的发生率显著更低。

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