Zhang Xiao, Liu Jian Jun, Fang Sum Chee, Ying Yeoh Lee, Tavintharan Subramaniam, Ng Xiao Wei, Su Chang, Low Serena, Lee Simon Bm, Tang Wern Ee, Lim Su Chi
Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore.
Diabetes Centre, Khoo Teck Puat Hospital, Singapore, Republic of Singapore Department of Medicine, Khoo Teck Puat Hospital, Singapore, Republic of Singapore.
Diab Vasc Dis Res. 2016 Jul;13(4):303-6. doi: 10.1177/1479164116635021. Epub 2016 Apr 18.
To examine the relationship between inflammation and central arterial stiffness in a type 2 diabetes Asian cohort.
Central arterial stiffness was estimated by carotid-femoral pulse wave velocity and augmentation index. Linear regression model was used to evaluate the association of high-sensitivity C-reactive protein and soluble receptor for advanced glycation end products with pulse wave velocity and augmentation index. High-sensitivity C-reactive protein was analysed as a continuous variable and categories (<1, 1-3, and >3 mg/L).
There is no association between high-sensitivity C-reactive protein and pulse wave velocity. Augmentation index increased with high-sensitivity C-reactive protein as a continuous variable (β = 0.328, p = 0.049) and categories (β = 1.474, p = 0.008 for high-sensitivity C-reactive protein: 1-3 mg/L and β = 1.323, p = 0.019 for high-sensitivity C-reactive protein: >3 mg/L) after multivariable adjustment. No association was observed between augmentation index and soluble receptor for advanced glycation end products. Each unit increase in natural log-transformed soluble receptor for advanced glycation end products was associated with 0.328 m/s decrease in pulse wave velocity after multivariable adjustment (p = 0.007).
Elevated high-sensitivity C-reactive protein and decreased soluble receptor for advanced glycation end products are associated with augmentation index and pulse wave velocity, respectively, suggesting the potential role of systemic inflammation in the pathogenesis of central arterial stiffness in type 2 diabetes.
在2型糖尿病亚洲队列中研究炎症与中心动脉僵硬度之间的关系。
通过颈股脉搏波速度和增强指数评估中心动脉僵硬度。采用线性回归模型评估高敏C反应蛋白和晚期糖基化终产物可溶性受体与脉搏波速度和增强指数之间的关联。将高敏C反应蛋白作为连续变量以及分类（<1、1 - 3和>3mg/L）进行分析。
高敏C反应蛋白与脉搏波速度之间无关联。在多变量调整后，增强指数随高敏C反应蛋白作为连续变量而增加（β = 0.328，p = 0.049）以及分类增加（高敏C反应蛋白为1 - 3mg/L时β = 1.474，p = 0.008；高敏C反应蛋白>3mg/L时β = 1.323，p = 0.019）。未观察到增强指数与晚期糖基化终产物可溶性受体之间的关联。在多变量调整后，晚期糖基化终产物自然对数转换后的可溶性受体每增加一个单位，与脉搏波速度降低0.328m/s相关（p = 0.007）。
高敏C反应蛋白升高和晚期糖基化终产物可溶性受体降低分别与增强指数和脉搏波速度相关，提示全身炎症在2型糖尿病中心动脉僵硬度发病机制中的潜在作用。
