糖尿病对产前无症状菌尿的患病率无显著影响。

Diabetes Mellitus has no Significant Influence on the Prevalence of Antenatal Asymptomatic Bacteriuria.

作者信息

Mekapogu Nissi Priya, Gundela Swarnalatha, Avula Renuka Devi

机构信息

Postgraduate Scholar, Department of Microbiology, Kurnool Medical College , Kurnool, Andhra Pradesh, India .

Professor and Head, Department of Microbiology, Kurnool Medical College , Kurnool, Andhra Pradesh, India .

出版信息

J Clin Diagn Res. 2016 Apr;10(4):DC16-20. doi: 10.7860/JCDR/2016/14939.7632. Epub 2016 Apr 1.

DOI:10.7860/JCDR/2016/14939.7632

PMID:27190802

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4866100/

Abstract

INTRODUCTION

Diabetes is a known risk factor for asymptomatic bacteriuria (ASB). However, the influence of diabetes on antenatal ASB was previously not addressed.

AIM

The prevalence of ASB, effect of risk factors and type of isolates and susceptibility patterns were studied in diabetic pregnancy.

MATERIALS AND METHODS

A total of 311 pregnant women were recruited for this study of which 103 were diabetic and 208 non-diabetic. A clean catch midstream urine samples were collected and cultured. The isolates were identified and antibiotic sensitivity was studied. The data was analysed by Chi-square test.

RESULTS

The prevalence of ASB in diabetic pregnancy was 38.83% (40/10(3); 95% CI: 23.73 - 53.94) and in non-diabetic pregnancy was 37.98% (79/208; CI: 27.28- 48.68). The odds ratio was not significant 1.0225 (95% CU: 0.65 - 1.599; p=0.922) and associated factors such as age and gestational period had no effect. The major isolates were Escherichia coli (25.0%), Staphylococcus aureus (22.5%), Coagulase negative staphylococci (CONS) (20.00%), and Klebsiella pneumonia (20.00%) in diabetic pregnancy and CONS (31.7%), E.coli (24.0%) and K.pneumonia (16.5%) in non-diabetic pregnancy. The isolates of diabetic pregnancy showed highest susceptibility to nitrofurantoin (56.4%), gentamicin (38.5%) and cotrimoxazole (38.5%) whereas that of non-diabetic pregnancy to gentamicin (43.0%), azithromycin (32.9%) and norfloxacin (30.4). There was no significant (p<0.05) difference in the type and susceptibly of the isolates between diabetic and non-diabetic pregnancy.

CONCLUSION

Diabetes has no significant influence on the prevalence of ASB in diabetic pregnancy both in terms of isolates and antibiotic susceptibility pattern.

摘要

引言

糖尿病是无症状菌尿（ASB）的已知危险因素。然而，糖尿病对产前无症状菌尿的影响此前未得到探讨。

目的

研究糖尿病孕妇中无症状菌尿的患病率、危险因素的影响、分离菌株的类型及药敏模式。

材料与方法

本研究共招募了311名孕妇，其中103名患有糖尿病，208名无糖尿病。收集清洁中段尿样本并进行培养。鉴定分离菌株并研究抗生素敏感性。采用卡方检验分析数据。

结果

糖尿病孕妇中无症状菌尿的患病率为38.83%（40/103；95%可信区间：23.73 - 53.94），非糖尿病孕妇中为37.98%（79/208；可信区间：27.28 - 48.68）。优势比无统计学意义，为1.0225（95%可信区间：0.65 - 1.599；p = 0.922），年龄和孕周等相关因素无影响。糖尿病孕妇中主要分离菌株为大肠埃希菌（25.0%）、金黄色葡萄球菌（22.5%）、凝固酶阴性葡萄球菌（CONS）（20.00%）和肺炎克雷伯菌（20.00%），非糖尿病孕妇中为CONS（31.7%）、大肠埃希菌（24.0%）和肺炎克雷伯菌（16.5%）。糖尿病孕妇的分离菌株对呋喃妥因（56.4%）、庆大霉素（38.5%）和复方新诺明（38.5%）敏感性最高，而非糖尿病孕妇的分离菌株对庆大霉素（43.0%）、阿奇霉素（32.9%）和诺氟沙星（30.4%）敏感性最高。糖尿病孕妇和非糖尿病孕妇分离菌株的类型及药敏情况无显著（p<0.05）差异。