Mannarino E, Pasqualini L, Maragoni G, Orlandi U
II Dept. of Internal Medicine, University of Perugia, Italy.
Angiology. 1989 Jun;40(6):559-62. doi: 10.1177/000331978904000607.
Modifications in transcutaneous oxygen pressure (TcPO2), induced by the administration of 3 mg/kg/day buflomedil chlorhydrate for seven days were evaluated in 12 subjects suffering from peripheral vascular disease (PVD). After the treatment a significant increase in TcPO2 basal values was observed in Stage III and Stage IV PVD patients (+32.2%) while a significant reduction of 12% in the half-recovery time to basal values after an induced ischemia was recorded in Stage II PVD patients by the seventh day. Buflomedil did not, however, cause any significant variations in the ankle/arm pressure ratio or in the plethysmographic peak flow.
对12名外周血管疾病（PVD）患者进行评估，观察连续7天每天服用3mg/kg盐酸丁咯地尔所引起的经皮氧分压（TcPO2）变化。治疗后，III期和IV期PVD患者的TcPO2基础值显著升高（+32.2%），而II期PVD患者在第7天时，诱导缺血后恢复至基础值的半恢复时间显著缩短了12%。然而，丁咯地尔并未使踝/臂压力比值或体积描记法峰值血流出现任何显著变化。
