Ziebarth D, Kuldmäe L A
Zentralinstitut für Krebsforschung der Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.
Arch Geschwulstforsch. 1989;59(2):79-84.
The influence of a simple and a more complex diet on the formation of nitrosometamizole from sodium metamizole (analgin tablets) under simulated human gastric conditions was estimated with extremely different nitrite concentrations. Only with the complex diet and only with low nitrite concentrations, the formation of nitrosometamizole was distinctly lowered. The quantitative estimation of the formed amounts was done by a colorimetric method after extraction with dichloromethane.
在模拟人体胃部条件下,使用浓度差异极大的亚硝酸盐,评估了简单饮食和复杂饮食对安乃近(安乃近片)生成亚硝基安乃近的影响。仅在复杂饮食且亚硝酸盐浓度较低的情况下,亚硝基安乃近的生成量才明显降低。生成量的定量评估是在使用二氯甲烷萃取后,通过比色法进行的。