Olsen K R, Parel J M, Lee W, Hernandez E, Fliesler S J
Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 33101.
Arch Ophthalmol. 1989 May;107(5):735-41. doi: 10.1001/archopht.1989.01070010753040.
Mechanical retinal fixation is a useful tool in the armamentarium of vitreoretinal surgeons. Unfortunately, the use of metallic retinal tacks on a permanent basic mandates a retained intraocular foreign body that poses some potential for long-range toxic effects. Herein, we report the results of our initial experience with a temporary, biodegradable mechanical retinal fixation device ("biopin") in rabbits. When compared with metallic tacks, the biopins appeared to be well tolerated intraocularly, with minimal damage detectable at the light microscopic level. Disinsertion of the biopins occurred in 46% of the eyes within two weeks and in all eyes by four weeks. Initial signs of degradation of the biopins were observed at six weeks (median) in the ensectomized/vitrectomized eyes and at 12 weeks (median) in the nonvitrectomized eyes. Differences were found in the occurrence of retinal detachment between animals that underwent lensectomy/vitrectomy with insertion of two metallic tacks and animals that underwent insertion of one biopin without vitrectomy. The biopin has a potential as a vehicle for sustained release of pharmacologic agents to inhibit directly the development of vitreoretinal proliferation, thereby retarding or preventing subsequent retinal traction and detachment.
机械性视网膜固定术是玻璃体视网膜外科医生的有用工具。不幸的是，永久性使用金属视网膜钉意味着眼内残留异物，这存在一些潜在的长期毒性作用。在此，我们报告了我们在兔子身上使用临时可生物降解机械性视网膜固定装置（“生物针”）的初步经验结果。与金属钉相比，生物针在眼内似乎耐受性良好，在光镜下可检测到的损伤最小。46%的眼睛在两周内生物针脱出，所有眼睛在四周内生物针脱出。在切除晶状体/玻璃体的眼睛中，六周（中位数）时观察到生物针开始降解的最初迹象，在未进行玻璃体切除术的眼睛中，12周（中位数）时观察到生物针开始降解的最初迹象。在接受晶状体切除/玻璃体切除并插入两个金属钉的动物与未进行玻璃体切除术而插入一个生物针的动物之间，视网膜脱离的发生率存在差异。生物针有潜力作为一种载体，用于持续释放药理剂，直接抑制玻璃体视网膜增殖的发展，从而延缓或预防随后的视网膜牵拉和脱离。
