3,7'-双吲哚衍生物的简便合成
A Convenient Synthesis of 3,7'-Bisindole Derivatives.
作者信息
Liu Teng, Zhu Hong-You, Luo Da-Yun, Yan Sheng-Jiao, Lin Jun
机构信息
Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Guangdong Goodscend Pharm. Sci &Tech. Co., Ltd., Shantou 650091, China.
出版信息
Molecules. 2016 May 17;21(5):638. doi: 10.3390/molecules21050638.
An efficient and convenient method to synthesize highly functionalized 3,7'-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for easy access to various novel 3,7'-bisindole derivatives in moderate to good yields.
通过杂环烯酮缩胺（HKAs）与2-(1H-吲哚-3-基)环己-2,5-二烯-1,4-二酮衍生物在乙醇基溶剂中于室温下进行迈克尔加成和环缩合反应，开发了一种高效便捷的方法来合成高度官能化的3,7'-双吲哚衍生物。该策略提供了一种高效、环境友好的方法，能够以中等至良好的产率轻松获得各种新型3,7'-双吲哚衍生物。
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