腺苷酸环化酶上两个不同的腺苷敏感位点。
Two distinct adenosine-sensitive sites on adenylate cyclase.
作者信息
Londos C, Wolff J
出版信息
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5482-6. doi: 10.1073/pnas.74.12.5482.
Abstract
The effects of adenosine and adenosine analogs on adenylate cyclases from several tissues have been examined. Two adenosine-reactive sites have been identified: (i) the "R" site, occupancy of which usually leads to activation of cyclase and which requires integrity of the ribose ring for activity, and (ii) the "P" site, which mediates inhibition and requires integrity of the purine ring for activity. Biphasic effects of adenosine are explained by the presence of both sites on a single adenylate cyclase. Comparison of these data with those in the literature indicates that adenosine-reactive "P" and "R" sites are present generally.
摘要
已经研究了腺苷及腺苷类似物对几种组织中腺苷酸环化酶的作用。已鉴定出两个腺苷反应位点：（i）“R”位点，占据该位点通常会导致环化酶激活，且该位点的活性需要核糖环的完整性；（ii）“P”位点，介导抑制作用，且该位点的活性需要嘌呤环的完整性。腺苷的双相效应可通过单个腺苷酸环化酶上存在这两个位点来解释。将这些数据与文献中的数据进行比较表明，腺苷反应性“P”和“R”位点普遍存在。
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