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1
Two distinct adenosine-sensitive sites on adenylate cyclase.腺苷酸环化酶上两个不同的腺苷敏感位点。
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5482-6. doi: 10.1073/pnas.74.12.5482.
2
Characterization of the purine-reactive site of the rat testis cytosolic adenylate cyclase.
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3
Adenosine inhibition of calmodulin-sensitive adenylate cyclase from bovine cerebral cortex.腺苷对牛大脑皮层钙调蛋白敏感的腺苷酸环化酶的抑制作用。
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4
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Metal ion and guanine nucleotide regulation of the inhibition of lung adenylate cyclase by adenosine analogs.金属离子和鸟嘌呤核苷酸对腺苷类似物抑制肺腺苷酸环化酶的调节作用。
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8
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The role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multi-site transition states.腺嘌呤和鸟嘌呤核苷酸在腺苷酸环化酶系统对激素的活性及反应中的作用：多位点过渡态的证据
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International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.国际基础与临床药理学联合会。CI。哺乳动物腺苷酸环化酶的结构与小分子调节剂。
Pharmacol Rev. 2017 Apr;69(2):93-139. doi: 10.1124/pr.116.013078.
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Heart Fail Rev. 2010 Sep;15(5):495-512. doi: 10.1007/s10741-010-9183-5.
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Differential role of the carboxy-terminus of the A(2B) adenosine receptor in stimulation of adenylate cyclase, phospholipase Cbeta, and interleukin-8.A2B 腺苷受体羧基末端在刺激腺苷酸环化酶、磷脂酶 Cβ 和白细胞介素-8 中的差异作用。
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本文引用的文献

1
Role of adenine nucleotides, adenosine, and inorganic phosphate in the regulation of skeletal muscle blood flow.腺嘌呤核苷酸、腺苷和无机磷酸盐在骨骼肌血流调节中的作用。
Circ Res. 1971 Oct;29(4):375-84. doi: 10.1161/01.res.29.4.375.
2
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. I. Properties.大鼠肝脏质膜中对胰高血糖素敏感的腺苷酸环化酶系统。I. 特性。
J Biol Chem. 1971 Mar 25;246(6):1849-56.
3
A highly sensitive adenylate cyclase assay.一种高灵敏度的腺苷酸环化酶检测方法。
Anal Biochem. 1974 Apr;58(2):541-8. doi: 10.1016/0003-2697(74)90222-x.
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On the mechanism of adenyl cyclase inhibition by adenosine.关于腺苷对腺苷酸环化酶的抑制机制
Can J Physiol Pharmacol. 1973 Mar;51(3):190-6. doi: 10.1139/y73-027.
5
Cyclic adenosine 3',5'-monophosphate in guinea pig cerebral cortical slices. II. The role of phosphodiesterase activity in the regulation of levels of cyclic adenosine 3',5'-monophosphate.豚鼠大脑皮层切片中的环磷酸腺苷3',5'-单磷酸。II. 磷酸二酯酶活性在环磷酸腺苷3',5'-单磷酸水平调节中的作用。
J Biol Chem. 1973 Feb 10;248(3):853-9.
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Purinergic nerves.嘌呤能神经
Pharmacol Rev. 1972 Sep;24(3):509-81.
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Accumulation of cyclic adenosine monophosphate in incubated slices of brain tissue. 2. Effects of depolarizing agents, membrane stabilizers, phosphodiesterase inhibitors, and adenosine analogs.脑组织孵育切片中环磷酸腺苷的积累。2. 去极化剂、膜稳定剂、磷酸二酯酶抑制剂及腺苷类似物的作用。
J Med Chem. 1972 May;15(5):462-6. doi: 10.1021/jm00275a005.
8
Studies on receptor-mediated activation of adenylyl cyclases. II. Nucleotide and nucleoside regulation of the activities of the beef renal medullary adenylyl cyclase and their stimulation by neurohypophyseal hormones.受体介导的腺苷酸环化酶激活的研究。II. 牛肉肾髓质腺苷酸环化酶活性的核苷酸和核苷调节及其受神经垂体激素的刺激
J Biol Chem. 1974 Dec 25;249(24):7857-66.
9
Regulation of adenosine 3':5'-monophosphate content in human astrocytoma cells by adenosine and the adenine nucleotides.腺苷及腺嘌呤核苷酸对人星形细胞瘤细胞中3':5'-单磷酸腺苷含量的调节
J Biol Chem. 1974 Aug 25;249(16):5296-303.
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Adenosine-elicited accumulation of cyclic AMP in brain slices: potentiation by agents which inhibit uptake of adenosine.
Life Sci. 1974 Feb 1;14(3):489-503. doi: 10.1016/0024-3205(74)90364-6.

腺苷酸环化酶上两个不同的腺苷敏感位点。

Two distinct adenosine-sensitive sites on adenylate cyclase.

作者信息

Londos C, Wolff J

出版信息

Proc Natl Acad Sci U S A. 1977 Dec;74(12):5482-6. doi: 10.1073/pnas.74.12.5482.

DOI:10.1073/pnas.74.12.5482
PMID:271970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC431772/
Abstract

The effects of adenosine and adenosine analogs on adenylate cyclases from several tissues have been examined. Two adenosine-reactive sites have been identified: (i) the "R" site, occupancy of which usually leads to activation of cyclase and which requires integrity of the ribose ring for activity, and (ii) the "P" site, which mediates inhibition and requires integrity of the purine ring for activity. Biphasic effects of adenosine are explained by the presence of both sites on a single adenylate cyclase. Comparison of these data with those in the literature indicates that adenosine-reactive "P" and "R" sites are present generally.

摘要

已经研究了腺苷及腺苷类似物对几种组织中腺苷酸环化酶的作用。已鉴定出两个腺苷反应位点：（i）“R”位点，占据该位点通常会导致环化酶激活，且该位点的活性需要核糖环的完整性；（ii）“P”位点，介导抑制作用，且该位点的活性需要嘌呤环的完整性。腺苷的双相效应可通过单个腺苷酸环化酶上存在这两个位点来解释。将这些数据与文献中的数据进行比较表明，腺苷反应性“P”和“R”位点普遍存在。