Hu Guoqin, Yang Chengqing, Zhao Jing, Zhu Minghuan, Guo Xiangqing, Bao Chenxi, Jia Si, Xu Ahong, Jie Yong, Wang Zuowei, Zhang Chen, He Yongguang, Lv Qinyu, Yu Shunying, Yi Zhenghui
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mental Health Center of Hongkou District, Shanghai, China.
Shanghai Arch Psychiatry. 2015 Dec 25;27(6):348-55. doi: 10.11919/j.issn.1002-0829.215120.
Previous studies report that various single nucleotide polymorphisms (SNP) in the Disrupted-in Schizophrenia 1 (DISC1) gene are closely associated with schizophrenia, but there are no studies that assess the relationship of age of onset of schizophrenia with these SNPs.
Investigate the relationship between the rs821633 SNP in the DISC1 gene and the occurrence and age of onset of schizophrenia in Han Chinese.
We used the TaqMan genotyping technology to examine the rs821633 SNP in the DISC1 gene among 315 individuals who developed schizophrenia prior to 19 years of age ('early-onset'), 407 individuals who developed schizophrenia when 19 years of age or older ('late-onset'), and 482 healthy controls. We used survival analyses to investigate the relationship between the rs821633(C) risk allele and the age of onset of schizophrenia.
Compared to the prevalence in healthy controls, the prevalence of the C/C genotype of rs821633 and of the C allele in rs821633 were significantly greater in individuals with early-onset schizophrenia (X (2)=7.17, df=1, p=0.007; X (2)=7.20, df=2, p=0.032) and significantly greater in individuals with late-onset schizophrenia (X (2)=5.36, df=1, p=0.022; X (2)=6.58, df=2, p=0.041). However, there were no significant differences in the prevalence of the C/C genotype or the C allele between individuals with early-onset and late-onset schizophrenia. Kaplan-Meier survival analyses found no significant association between the rs821633(C) risk allele and age of onset in schizophrenia.
We confirm the association of polymorphism in the rs821633 SNP in the DISC1 gene with schizophrenia among Han Chinese, but we found no association between the rs821633(C) risk allele and the age of onset in individuals with schizophrenia.
既往研究报道，精神分裂症断裂基因1（DISC1）中的各种单核苷酸多态性（SNP）与精神分裂症密切相关，但尚无研究评估这些SNP与精神分裂症发病年龄之间的关系。
研究DISC1基因中rs821633 SNP与汉族人群精神分裂症的发生及发病年龄之间的关系。
我们使用TaqMan基因分型技术，检测了315例19岁之前发病的精神分裂症患者（“早发型”）、407例19岁及以上发病的精神分裂症患者（“晚发型”）以及482例健康对照者中DISC1基因的rs821633 SNP。我们使用生存分析来研究rs821633（C）风险等位基因与精神分裂症发病年龄之间的关系。
与健康对照者中的患病率相比，rs821633的C/C基因型和C等位基因在早发型精神分裂症患者中的患病率显著更高（X(2)=7.17，自由度=1，p=0.007；X(2)=7.20，自由度=2，p=0.032），在晚发型精神分裂症患者中也显著更高（X(2)=5.36，自由度=1，p=0.022；X(2)=6.58，自由度=2，p=0.041）。然而，早发型和晚发型精神分裂症患者之间C/C基因型或C等位基因的患病率没有显著差异。Kaplan-Meier生存分析发现，rs821633（C）风险等位基因与精神分裂症的发病年龄之间没有显著关联。
我们证实了汉族人群中DISC1基因rs821633 SNP的多态性与精神分裂症有关，但我们发现rs821633（C）风险等位基因与精神分裂症患者的发病年龄之间没有关联。
