Ede Hüseyin, Tanik Serhat, Yaylak Barış, Zengın Kürşad, Albayrak Sebahattin, Akkaya Suleyman, Polat Cegergun, Turan Yaşar, Erbay Alirıza
Department of Cardiology, Faculty of Medicine, Bozok University, 66020 Yozgat, Turkey.
Department of Urology, Faculty of Medicine, Bozok University, 66020 Yozgat, Turkey.
Scientifica (Cairo). 2016;2016:4867984. doi: 10.1155/2016/4867984. Epub 2016 Apr 21.
Objective. Vardenafil is used in treatment of erectile dysfunction (ED) but reveals variable clinical outcomes. Here, we aimed to evaluate the role of aortic elasticity in predicting vardenafil success among patients with ED. Methods. Sixty-one consecutive male subjects with primary ED and indication for vardenafil treatment were included. All subjects fulfilled 5-item version of the International Index of Erectile Function (IIEF-5) before the vardenafil treatment. Pretreatment aortic stiffness index (ASI) and aortic distensibility (AD) were obtained echocardiographically. Following two-month vardenafil treatment, the patients were reevaluated with IIEF-5. Pretreatment, posttreatment, and ΔIIEF-5 scores and ASI values were compared. Results. Average age was 54 ± 8 years. Pretreatment and posttreatment IIEF-5 and ΔIIEF-5 scores were 9.1 ± 2.5; 18.5 ± 2.3; and 9.4 ± 3, respectively. Mean ASI and AD values were 3.10 ± 0.54 and 4.13 ± 2.55 1/(10(3) × mmHg) accordingly. ASI value of severe pretreatment ED (n = 15) was significantly higher than that of mild-moderate pretreatment ED (n = 12) (p < 0.001). All pretreatment IIEF-5 scores increased significantly compared to posttreatment IIEF-5 scores (p < 0.001). ASI values were significantly correlated to pretreatment IIEF-5 scores (p < 0.001) and ΔIIEF-5 value (p < 0.001) but not to posttreatment IIEF-5 score. Conclusion. Aortic elasticity was impaired in accordance with degree of ED. The subjects with higher ASI values obtained more benefits from vardenafil.
目的。伐地那非用于治疗勃起功能障碍（ED），但临床疗效存在差异。在此，我们旨在评估主动脉弹性在预测ED患者伐地那非治疗效果中的作用。方法。纳入61例连续的原发性ED且有伐地那非治疗指征的男性受试者。所有受试者在接受伐地那非治疗前均完成了5项版国际勃起功能指数（IIEF-5）评估。通过超声心动图获得治疗前的主动脉僵硬度指数（ASI）和主动脉扩张性（AD）。经过两个月的伐地那非治疗后，用IIEF-5对患者进行重新评估。比较治疗前、治疗后以及IIEF-5评分和ASI值的变化。结果。平均年龄为54±8岁。治疗前、治疗后以及IIEF-5评分变化值分别为9.1±2.5；18.5±2.3；以及9.4±3。相应地，平均ASI和AD值分别为3.10±0.54和4.13±2.55 1/(10(3)×mmHg)。重度治疗前ED患者（n = 15）的ASI值显著高于轻度至中度治疗前ED患者（n = 12）（p < 0.001）。与治疗后IIEF-5评分相比，所有治疗前IIEF-5评分均显著升高（p < 0.001）。ASI值与治疗前IIEF-5评分（p < 0.001）和IIEF-5评分变化值（p < 0.001）显著相关，但与治疗后IIEF-5评分无关。结论。主动脉弹性根据ED程度受损。ASI值较高的受试者从伐地那非中获益更多。
