一种A2嘌呤受体激动剂NECA可增强乙酰胆碱诱导的胰高血糖素分泌。
An A2-purinoceptor agonist, NECA, potentiates acetylcholine-induced glucagon secretion.
作者信息
Bertrand G, Gross R, Petit P, Loubatières-Mariani M M
机构信息
Faculté de Médecine, URA 599 du CNRS, Montpellier, France.
出版信息
Br J Pharmacol. 1989 Mar;96(3):500-2. doi: 10.1111/j.1476-5381.1989.tb11844.x.
The effect of a stable structural analogue of adenosine, 5'-N-ethylcarboxamidoadenosine (NECA), was studied on glucagon secretion induced by acetylcholine (ACh) in the isolated perfused pancreas of the newborn dog. The perfusion solution contained a physiological concentration of glucose (4.2 mM). In the first set of experiments, ACh (0.5 microM) infused alone for 10 min induced a significant rise of glucagon secretion (370 +/- 98%, 4 min after the beginning of infusion). In the second set, NECA (2.2 nM) infused 10 min before ACh administration, had no effect per se, but considerably increased the response to ACh (929 +/- 262% of basal value within 3 min). So, the more specific A2 purinoceptor agonist, NECA, potentiated glucagon secretion induced by the cholinoceptor agonist, ACh.
研究了腺苷的一种稳定结构类似物5'-N-乙基甲酰胺基腺苷（NECA）对新生犬离体灌注胰腺中乙酰胆碱（ACh）诱导的胰高血糖素分泌的影响。灌注液含有生理浓度的葡萄糖（4.2 mM）。在第一组实验中，单独输注ACh（0.5 μM）10分钟可诱导胰高血糖素分泌显著升高（输注开始后4分钟，升高370±98%）。在第二组实验中，在给予ACh前10分钟输注NECA（2.2 nM），其本身无作用，但显著增强了对ACh的反应（3分钟内为基础值的929±262%）。因此，更具特异性的A2嘌呤受体激动剂NECA增强了胆碱受体激动剂ACh诱导的胰高血糖素分泌。
Zotero 插件