School of Biological Sciences, Victoria University of Wellington, Wellington 6140, New Zealand.
Cell Chem Biol. 2016 May 19;23(5):535-537. doi: 10.1016/j.chembiol.2016.05.001.
Landmark achievements in chemical and structural biology have advanced our understanding of nonribosomal peptide synthetase mechanisms. However, nature's proven ability to re-engineer these enzymes remains difficult to recapitulate synthetically. In a recent issue of Cell Chemical Biology, Meyer et al. (2016) sought to extract new clues from old (evolutionary) evidence.
化学和结构生物学领域的里程碑式成就推动了我们对非核糖体肽合成酶机制的理解。然而，大自然对这些酶进行再工程的能力仍然难以在合成上重现。在最近一期的《细胞化学生物学》杂志上，Meyer 等人（2016 年）试图从旧（进化）证据中提取新的线索。
