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用于双胎输血综合征的所罗门技术与选择性凝血法

Solomon Technique Versus Selective Coagulation for Twin-Twin Transfusion Syndrome.

作者信息

Slaghekke Femke, Oepkes Dick

机构信息

Division of Fetal Medicine,Department of Obstetrics,Leiden University Medical Centre,the Netherlands.

出版信息

Twin Res Hum Genet. 2016 Jun;19(3):217-21. doi: 10.1017/thg.2016.25.

DOI:10.1017/thg.2016.25
PMID:27203607
Abstract

Monochorionic twin pregnancies can be complicated by twin-to-twin transfusion syndrome (TTTS). The best treatment option for TTTS is fetoscopic laser coagulation of the vascular anastomoses between donor and recipient. After laser therapy, up to 33% residual anastomoses were seen. These residual anastomoses can cause twin anemia polycythemia sequence (TAPS) and recurrent TTTS. In order to reduce the number of residual anastomoses and their complications, a new technique, the Solomon technique, where the whole vascular equator will be coagulated, was introduced. The Solomon technique showed a reduction of recurrent TTS compared to the selective technique. The incidence of recurrent TTTS after the Solomon technique ranged from 0% to 3.9% compared to 5.3-8.5% after the selective technique. The incidence of TAPS after the Solomon technique ranged from 0% to 2.9% compared to 4.2-15.6% after the selective technique. The Solomon technique may improve dual survival rates ranging from 64% to 85% compared to 46-76% for the selective technique. There was no difference reported in procedure-related complications such as intrauterine infection and preterm premature rupture of membranes. The Solomon technique significantly reduced the incidence of TAPS and recurrent TTTS and may improve survival and neonatal outcome, without identifiable adverse outcome or complications; therefore, the Solomon technique is recommended for the treatment of TTTS.

摘要

单绒毛膜双胎妊娠可能并发双胎输血综合征(TTTS)。TTTS的最佳治疗选择是胎儿镜下激光凝固供血儿与受血儿之间的血管吻合支。激光治疗后,可见高达33%的残余吻合支。这些残余吻合支可导致双胎贫血红细胞增多序列(TAPS)和复发性TTTS。为了减少残余吻合支的数量及其并发症,引入了一种新技术——所罗门技术,即对整个血管赤道进行凝固。与选择性技术相比,所罗门技术显示复发性TTS有所减少。所罗门技术后复发性TTTS的发生率为0%至3.9%,而选择性技术后为5.3%至8.5%。所罗门技术后TAPS的发生率为0%至2.9%,而选择性技术后为4.2%至15.6%。与选择性技术的46%至76%相比,所罗门技术可能使双胎存活率提高到64%至85%。在诸如宫内感染和胎膜早破等与手术相关的并发症方面,未报告有差异。所罗门技术显著降低了TAPS和复发性TTTS的发生率,可能改善存活率和新生儿结局,且无明显不良结局或并发症;因此,推荐采用所罗门技术治疗TTTS。

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