纳米尺度孔中单原子杂多钨酸盐及其异构体在溶液中的单分子分辨
Single Molecule Discrimination of Heteropolytungstates and Their Isomers in Solution with a Nanometer-Scale Pore.
机构信息
Engineering Physics Division, Physical Measurement Laboratory, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
Department of Chemical Engineering, Columbia University , New York, New York 10027-6623, United States.
出版信息
J Am Chem Soc. 2016 Jun 15;138(23):7228-31. doi: 10.1021/jacs.6b02917. Epub 2016 Jun 2.
We report a new method to identify metallic nanoclusters (polyoxometalate structures) in solution at the single molecule limit using a nanometer-scale pore. The technique allows the measurement of polyoxometalates with over 2 orders of magnitude lower analyte concentration than conventional analytical chemistry tools. Furthermore, pH-dependent structural changes in phosphotungstic acid are measured with protein nanopores and validated with NMR. We further demonstrate that the method can also discriminate PW9O34 structural isomers. The results suggest this technique can serve as a complementary approach to traditional methods.
我们报告了一种新的方法，可以使用纳米级孔在单分子极限下识别溶液中的金属纳米团簇（多金属氧酸盐结构）。该技术允许测量多金属氧酸盐，其分析物浓度比传统分析化学工具低两个数量级以上。此外，还使用蛋白纳米孔测量了磷钨酸的 pH 依赖性结构变化，并通过 NMR 进行了验证。我们进一步证明该方法还可以区分PW9O34结构异构体。结果表明，该技术可以作为传统方法的补充方法。
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