Key Laboratory for Advanced Materials and Institute of Fine Chemicals & Department of Chemistry, East China University of Science and Technology Shanghai, PR China.
Chem Commun (Camb). 2013 Feb 28;49(17):1741-3. doi: 10.1039/c3cc38939a.
SP1 protein as a new type of biological nanopore is described and is utilized to distinguish single-stranded DNA at the single-molecule level. Using the SP1 nanopore to investigate single molecule detection broadens the existing research areas of pore-forming biomaterials from unsymmetrical biological nanopores to symmetrical biological nanopores. This novel nanopore could provide a good candidate for single-molecule detection and characterization of biomaterial applications.
SP1 蛋白作为一种新型生物纳米孔被描述，并被用于在单分子水平上区分单链 DNA。利用 SP1 纳米孔进行单分子检测拓宽了现有孔形成生物材料的研究领域，从非对称生物纳米孔扩展到对称生物纳米孔。这种新型纳米孔为生物材料的单分子检测和特性分析提供了一个很好的候选。
