格雷夫斯甲亢合并急性乙型肝炎病毒感染：一种肝外表现？
Graves' hyperthyroidism accompanied with acute hepatitis B virus infection: an extrahepatic manifestation?
作者信息
Cui Wei, Deng Baocheng, Wang Wen, Liu Pei
机构信息
Department of Infectious Diseases, the First Affiliated Hospital, China Medical University, Shenyang, China.
出版信息
Virol J. 2016 May 20;13:80. doi: 10.1186/s12985-016-0537-z.
BACKGROUND
Although hepatitis B virus (HBV) primarily affects hepatocytes, it has also been shown to cause complications in the skin, joints, muscles, and kidneys. Thyroid dysfunction is uncommon in cases of acute HBV infection.
CASE PRESENTATION
In this report, we describe a case of a 46-year-old woman with incipient acute hepatitis B virus (HBV) infection who presented clinically with Graves' hyperthyroidism. She showed typical symptoms of hyperthyroidism, and laboratory tests revealed high levels of HBV DNA and alanine transaminase (ALT). The patient was not administered with antithyroid medicine or radioiodine, but she was given antiviral therapy and symptomatic treatment with propranolol. Follow-up studies showed that as the HBV DNA levels decreased, the thyroid function recovered.
CONCLUSION
Graves' disease maybe an extrahepatic manifestation of acute HBV infection. Antiviral therapy is likely to be beneficial for this condition as without severe thyrotoxicosis.
背景
尽管乙型肝炎病毒（HBV）主要影响肝细胞，但也已证明它会导致皮肤、关节、肌肉和肾脏出现并发症。甲状腺功能障碍在急性HBV感染病例中并不常见。
病例报告
在本报告中，我们描述了一例46岁初发急性乙型肝炎病毒（HBV）感染的女性患者，临床上表现为格雷夫斯甲亢。她表现出典型的甲亢症状，实验室检查显示HBV DNA和丙氨酸转氨酶（ALT）水平升高。该患者未接受抗甲状腺药物或放射性碘治疗，但接受了抗病毒治疗及普萘洛尔对症治疗。随访研究表明，随着HBV DNA水平下降，甲状腺功能恢复。
结论
格雷夫斯病可能是急性HBV感染的一种肝外表现。对于这种无严重甲状腺毒症的情况，抗病毒治疗可能有益。
Zotero 插件