β淀粉样蛋白在阿尔茨海默病血管和炎症功能障碍中的一种可能新作用。
A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease.
作者信息
Zamolodchikov Daria, Strickland Sidney
机构信息
Laboratory of Neurobiology and Genetics; The Rockefeller University; New York, NY 10065, USA.
Laboratory of Neurobiology and Genetics; The Rockefeller University; New York, NY 10065, USA.
出版信息
Thromb Res. 2016 May;141 Suppl 2:S59-61. doi: 10.1016/S0049-3848(16)30367-X.
Alzheimer's disease (AD) is often characterized by vascular pathology, a procoagulant state, and chronic inflammation. The mechanisms behind these abnormalities in AD are not clear. Here, we review evidence for the role of the AD-associated peptide Aβ in promoting inflammation and thrombosis in AD via its interaction with the circulating proteins factor XII and fibrinogen.
阿尔茨海默病（AD）通常以血管病变、促凝状态和慢性炎症为特征。AD中这些异常背后的机制尚不清楚。在此，我们综述了与AD相关的肽Aβ通过与循环蛋白因子XII和纤维蛋白原相互作用在促进AD炎症和血栓形成中作用的证据。
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