Gong Liang, Yin Jiayi, Zhang Yu, Huang Ren, Lou Yuxuan, Jiang Haojie, Sun Liyan, Jia Jinjing, Zeng Xiansi
Jiaxing University Medical College, Jiaxing, China.
Department of Clinical Medicine, Jiaxing University Medical College, Jiaxing, China.
Front Pharmacol. 2022 Jun 2;13:914352. doi: 10.3389/fphar.2022.914352. eCollection 2022.
Panax ginseng and Panax notoginseng, two well-known herbs with enormous medical value in Asian countries, have a long usage history in China for the therapy of some diseases, such as stroke. Ginsenoside Rb1 is one of most important active ingredients in Panax ginseng and Panax notoginseng. In the last two decades, more attention has focused on ginsenoside Rb1 as an antioxidative, anti-apoptotic and anti-inflammatory agent that can protect the nervous system. In the review, we summarize the neuroprotective roles of ginsenoside Rb1 and its potential mechanisms in central nervous system diseases (CNSDs), including neurodegenerative diseases, cerebral ischemia injury, depression and spinal cord injury. In conclusion, ginsenoside Rb1 has a potential neuroprotection due to its inhibition of oxidative stress, apoptosis, neuroinflammation and autophagy in CNSDs and may be a promising candidate agent for clinical therapy of CNSDs in the future.
人参和三七是亚洲国家两种具有巨大医学价值的著名草药，在中国用于治疗中风等一些疾病已有很长的使用历史。人参皂苷Rb1是人参和三七中最重要的活性成分之一。在过去二十年中，人参皂苷Rb1作为一种抗氧化、抗凋亡和抗炎剂，能够保护神经系统，受到了更多关注。在这篇综述中，我们总结了人参皂苷Rb1在中枢神经系统疾病（CNSDs）中的神经保护作用及其潜在机制，这些疾病包括神经退行性疾病、脑缺血损伤、抑郁症和脊髓损伤。总之，人参皂苷Rb1因其在中枢神经系统疾病中抑制氧化应激、细胞凋亡、神经炎症和自噬而具有潜在的神经保护作用，可能是未来中枢神经系统疾病临床治疗中一种有前景的候选药物。
