Synthesis and antiulcer activity of the metabolites of 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline dimaleate (AS-2646), a novel gastric antisecretory and antiulcer agent.
作者信息
Hino K, Kawashima K, Oka M, Uno H, Matsumoto J
出版信息
Chem Pharm Bull (Tokyo). 1989 Jan;37(1):190-2. doi: 10.1248/cpb.37.190.
PMID:2720848
Abstract
The metabolites 3 and 4 of 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline dimaleate (AS-2646, 1), a candidate as a gastric antisecretory and antiulcer drug, were synthesized to confirm the proposed structures. The effects of the metabolites 2-4 on ulcer induced by stress were determined.
摘要
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