Speich M, Auget J L, Arnaud P
Laboratoire de Biochimie Pharmaceutique, Faculté de Pharmacie, Nantes, France.
Clin Chem. 1989 May;35(5):833-5.
We present a statistical interpretation of plasma (Pl) and (or) erythrocyte (Erc) concentrations of magnesium, zinc, calcium, potassium, and total high-density lipoprotein (HDL) cholesterol, as well as of the activity of total creatine kinase (CK) and its CK-MB isoenzyme, in 26 men with pre-infarction syndrome (PIS) and 34 men with acute myocardial infarction (MI). Discriminant analysis allowed overall comparison of both groups and determination of the most significant variables: CK and Pl-Zn. By non-hierarchical cluster analysis we defined three homogeneous subgroups among MI men, with CK, CK-MB, and Pl-Zn differing significantly between the groups. In PIS men, Pl-Zn was correlated with Pl-Ca, whereas in MI men Pl-Zn was correlated with Pl-Mg. Stepwise regression indicated that Pl-Zn was the most significant regressor of CK in PIS men and of CK-MB in MI men. All these statistical interpretations support a special role of Pl-Zn in diagnosis and perhaps prognosis. After MI, interleukin-1 release may possibly mediate observed hypozincemia via formation of a heart Zn-metallothionein.
我们对26例患有梗死前综合征（PIS）的男性和34例患有急性心肌梗死（MI）的男性的血浆（Pl）和（或）红细胞（Erc）中的镁、锌、钙、钾浓度，以及总高密度脂蛋白（HDL）胆固醇浓度，还有总肌酸激酶（CK）及其CK-MB同工酶的活性进行了统计学解释。判别分析使得能够对两组进行全面比较，并确定最显著的变量：CK和血浆锌（Pl-Zn）。通过非分层聚类分析，我们在心肌梗死男性中定义了三个同质亚组，各组之间的CK、CK-MB和血浆锌差异显著。在梗死前综合征男性中，血浆锌与血浆钙相关，而在心肌梗死男性中，血浆锌与血浆镁相关。逐步回归表明，血浆锌是梗死前综合征男性中CK以及心肌梗死男性中CK-MB的最显著回归因子。所有这些统计学解释都支持血浆锌在诊断乃至预后方面的特殊作用。心肌梗死后，白细胞介素-1的释放可能通过形成心脏锌金属硫蛋白来介导观察到的低锌血症。
