Sung Ki Hyuk, Chung Chin Youb, Lee Kyoung Min, Lee Jaebong, Chung Myung Ki, Cho Byung Chae, Moon Seung Jun, Park Moon Seok
Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Kyungki, Republic of Korea.
Medical Research Collaboration Center, Seoul National University Bundang Hospital, Kyungki, Republic of Korea.
J Clin Densitom. 2017 Jan-Mar;20(1):114-119. doi: 10.1016/j.jocd.2016.04.007. Epub 2016 May 17.
This pilot study was performed to evaluate the correlation between central bone mineral density (BMD) and peripheral BMD around the elbow in children and adolescents and to compare BMD values across skeletal sites. Twenty-seven healthy volunteers between 5 and 18 yr of age were recruited for the study. Anthropometric measurements including height and weight were performed. Central BMD at the lumbar spine and left femur and peripheral BMD at the supracondylar area, medial condyle, lateral condyle, and olecranon were measured using dual-energy X-ray absorptiometry (DXA). Higher BMD levels were found in the central skeleton (lumbar spine and femur) than in peripheral sites around the elbow (p < 0.001). BMD values around the elbow ranged from 44.4% to 63.2% compared to the BMD values of the central skeleton. Among the peripheral sites around the elbow, the highest BMD was observed at the supracondylar area and olecranon, and the lowest BMD was found at the lateral condyle. Peripheral DXA measurements around the elbow were significantly correlated with central DXA measurements at the lumbar spine and femur. In conclusion, this study demonstrated that the measurements of BMD around the elbow were correlated with BMD at central sites. Given the small sample size in this pilot study, further study with a large cohort is required to use the BMD measurements around the elbow as a valid clinical tool for fracture risk assessment and population-based epidemiological studies.
本前瞻性研究旨在评估儿童和青少年的中心骨密度（BMD）与肘部周围外周骨密度之间的相关性，并比较不同骨骼部位的骨密度值。本研究招募了27名年龄在5至18岁之间的健康志愿者。进行了包括身高和体重在内的人体测量。使用双能X线吸收法（DXA）测量腰椎和左股骨的中心骨密度以及髁上区域、内侧髁、外侧髁和鹰嘴的外周骨密度。发现中心骨骼（腰椎和股骨）的骨密度水平高于肘部周围的外周部位（p<0.001）。与中心骨骼的骨密度值相比，肘部周围的骨密度值范围为44.4%至63.2%。在肘部周围的外周部位中，髁上区域和鹰嘴的骨密度最高，外侧髁的骨密度最低。肘部周围的外周DXA测量值与腰椎和股骨的中心DXA测量值显著相关。总之，本研究表明肘部周围的骨密度测量值与中心部位的骨密度相关。鉴于本前瞻性研究的样本量较小，需要进一步开展大样本队列研究，以便将肘部周围的骨密度测量作为骨折风险评估和基于人群的流行病学研究的有效临床工具。
