Department of Surgery, Committee on Molecular Medicine and Pathology, Basic Science Division, University of Chicago, Chicago, IL, USA.
Department of Surgery, Committee on Molecular Medicine and Pathology, Basic Science Division, University of Chicago, Chicago, IL, USA.
Trends Endocrinol Metab. 2016 Aug;27(8):563-573. doi: 10.1016/j.tem.2016.04.015. Epub 2016 May 19.
Cardiovascular diseases (CVDs) are expanding at an alarming rate and people's propensity to develop them increases with age. Growing evidence indicates that sirtuins play a pivotal role in regulating a multitude of age-related diseases. Sirtuins are versatile molecules conserved from archaea to mammals. They are regulated by various metabolic and environmental stimuli. Seven sirtuin homologs (SIRT1-7) are present in mammals, with diverse cellular locations. Recent studies have delineated roles of sirtuins in regulating cardiac pathophysiological conditions under various stressors. SIRT1 is the most extensively studied sirtuin, while the role of other sirtuins in maintaining cardiac growth and function is still emerging. In this review we discuss the present understanding of the role of sirtuins in regulating pathophysiological conditions of the heart.
心血管疾病（CVDs）的发病率正以惊人的速度上升，人们患 CVDs 的倾向随着年龄的增长而增加。越来越多的证据表明，沉默信息调节因子 2 相关酶（sirtuins）在调节多种与年龄相关的疾病方面发挥着关键作用。sirtuins 是一种从古菌到哺乳动物中都保守的多功能分子，它们受到多种代谢和环境刺激的调节。哺乳动物中有 7 种 sirtuins 同源物（SIRT1-7），它们在细胞中的位置各不相同。最近的研究阐明了 sirtuins 在调节各种应激源下心脏病理生理状态中的作用。SIRT1 是研究最多的 sirtuins，而其他 sirtuins 在维持心脏生长和功能中的作用仍在不断涌现。在这篇综述中，我们讨论了 sirtuins 在调节心脏病理生理状态中的作用的现有认识。
